| Interaction between FKBP5 and childhood trauma and risk of aggressive behavior. | |
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MedLine Citation:
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PMID: 22213790 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Childhood trauma may predispose individuals to aggressive behavior, and both childhood trauma and aggressive behavior are associated with hypothalamic-pituitary-adrenal axis dysregulation. OBJECTIVE: To determine whether there would be an interaction between genetic variation in FKBP5 and childhood trauma in predicting aggressive behavior. DESIGN: Cross-sectional study. Four FKBP5 single-nucleotide polymorphisms used in previous studies (rs3800373, rs9296158, rs1360780, and rs9470080) were genotyped. Three diplotypes were derived from 2 major putatively functional haplotypes regulating protein expression that were previously associated with glucocorticoid receptor sensitivity. SETTING: Penitentiary District of Abruzzo-Molise in central Italy. PARTICIPANTS: A population of 583 male Italian prisoners recruited between 2005 and 2008. MAIN OUTCOME MEASURES: A comprehensive analysis of aggression and impulsivity was undertaken using the Brown-Goodwin Lifetime History of Aggression (BGHA) questionnaire, the Buss-Durkee Hostility Inventory (BDHI), and the Barratt Impulsiveness Scale (BIS). A history of childhood trauma was investigated with the Childhood Trauma Questionnaire. The interaction between the FKBP5 diplotypes and childhood trauma on measures of aggression was analyzed. Analyses were replicated with a second behavioral measure of aggression: violent behavior in jail. Individual single-nucleotide polymorphism analysis was performed. RESULTS: Childhood trauma had a significant effect on BGHA and BDHI scores but not on BIS scores. We observed a significant influence of the FKBP5 high-expression diplotype on both a lifetime history of aggressive behavior (BGHA) (P = .012) and violent behavior in jail (P = .025) but only in individuals exposed to childhood trauma, in particular to physical abuse. No main effect of the FKBP5 diplotypes was observed. CONCLUSION: These data suggest that childhood trauma and variants in the FKBP5 gene may interact to increase the risk of overt aggressive behavior. |
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Authors:
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Laura Bevilacqua; Vladimir Carli; Marco Sarchiapone; Danielle K George; David Goldman; Alec Roy; Mary-Anne Enoch |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Archives of general psychiatry Volume: 69 ISSN: 1538-3636 ISO Abbreviation: Arch. Gen. Psychiatry Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-03 Completed Date: 2012-02-22 Revised Date: 2012-09-28 |
Medline Journal Info:
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Nlm Unique ID: 0372435 Medline TA: Arch Gen Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 62-70 Citation Subset: AIM; IM |
Affiliation:
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LNG/NIAAA, NIH, Rockville, MD 20852, USA. laurabevilacqua27@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Adult Survivors of Child Abuse / psychology Aged Aged, 80 and over Aggression / physiology*, psychology Cross-Sectional Studies Genetic Variation Humans Impulsive Behavior / genetics* Interview, Psychological Italy Male Middle Aged Prisoners / psychology Risk Factors Tacrolimus Binding Proteins / genetics* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01 DA 10336-02/DA/NIDA NIH HHS; Z01 AA000301-09/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 5.2.1.-/Tacrolimus Binding Proteins; EC 5.2.1.8/tacrolimus binding protein 5 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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