Document Detail

Interaction between FKBP5 and childhood trauma and risk of aggressive behavior.
MedLine Citation:
PMID:  22213790     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Childhood trauma may predispose individuals to aggressive behavior, and both childhood trauma and aggressive behavior are associated with hypothalamic-pituitary-adrenal axis dysregulation.
OBJECTIVE: To determine whether there would be an interaction between genetic variation in FKBP5 and childhood trauma in predicting aggressive behavior.
DESIGN: Cross-sectional study. Four FKBP5 single-nucleotide polymorphisms used in previous studies (rs3800373, rs9296158, rs1360780, and rs9470080) were genotyped. Three diplotypes were derived from 2 major putatively functional haplotypes regulating protein expression that were previously associated with glucocorticoid receptor sensitivity.
SETTING: Penitentiary District of Abruzzo-Molise in central Italy.
PARTICIPANTS: A population of 583 male Italian prisoners recruited between 2005 and 2008.
MAIN OUTCOME MEASURES: A comprehensive analysis of aggression and impulsivity was undertaken using the Brown-Goodwin Lifetime History of Aggression (BGHA) questionnaire, the Buss-Durkee Hostility Inventory (BDHI), and the Barratt Impulsiveness Scale (BIS). A history of childhood trauma was investigated with the Childhood Trauma Questionnaire. The interaction between the FKBP5 diplotypes and childhood trauma on measures of aggression was analyzed. Analyses were replicated with a second behavioral measure of aggression: violent behavior in jail. Individual single-nucleotide polymorphism analysis was performed.
RESULTS: Childhood trauma had a significant effect on BGHA and BDHI scores but not on BIS scores. We observed a significant influence of the FKBP5 high-expression diplotype on both a lifetime history of aggressive behavior (BGHA) (P = .012) and violent behavior in jail (P = .025) but only in individuals exposed to childhood trauma, in particular to physical abuse. No main effect of the FKBP5 diplotypes was observed.
CONCLUSION: These data suggest that childhood trauma and variants in the FKBP5 gene may interact to increase the risk of overt aggressive behavior.
Laura Bevilacqua; Vladimir Carli; Marco Sarchiapone; Danielle K George; David Goldman; Alec Roy; Mary-Anne Enoch
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Archives of general psychiatry     Volume:  69     ISSN:  1538-3636     ISO Abbreviation:  Arch. Gen. Psychiatry     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-03     Completed Date:  2012-02-22     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0372435     Medline TA:  Arch Gen Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  62-70     Citation Subset:  AIM; IM    
LNG/NIAAA, NIH, Rockville, MD 20852, USA.
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MeSH Terms
Adult Survivors of Child Abuse / psychology
Aged, 80 and over
Aggression / physiology*,  psychology
Cross-Sectional Studies
Genetic Variation
Impulsive Behavior / genetics*
Interview, Psychological
Middle Aged
Prisoners / psychology
Risk Factors
Tacrolimus Binding Proteins / genetics*
Young Adult
Grant Support
R01 DA 10336-02/DA/NIDA NIH HHS; Z01 AA000301-09/AA/NIAAA NIH HHS
Reg. No./Substance:
EC 5.2.1.-/Tacrolimus Binding Proteins; EC binding protein 5

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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