Document Detail


Interaction between behavioral and pharmacological treatment strategies to decrease cocaine choice in rhesus monkeys.
MedLine Citation:
PMID:  22968813     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Behavioral and pharmacotherapeutic approaches constitute two prominent strategies for treating cocaine dependence. This study investigated interactions between behavioral and pharmacological strategies in a preclinical model of cocaine vs food choice. Six rhesus monkeys, implanted with a chronic indwelling double-lumen venous catheter, initially responded under a concurrent schedule of food delivery (1-g pellets, fixed-ratio (FR) 100 schedule) and cocaine injections (0-0.1 mg/kg/injection, FR 10 schedule) during continuous 7-day treatment periods with saline or the agonist medication phenmetrazine (0.032-0.1 mg/kg/h). Subsequently, the FR response requirement for cocaine or food was varied (food, FR 100; cocaine, FR 1-100; cocaine, FR 10; food, FR 10-300), and effects of phenmetrazine on cocaine vs food choice were redetermined. Decreases in the cocaine FR or increases in the food FR resulted in leftward shifts in the cocaine choice dose-effect curve, whereas increases in the cocaine FR or decreases in the food FR resulted in rightward shifts in the cocaine choice dose-effect curve. The efficacy of phenmetrazine to decrease cocaine choice varied systematically as a function of the prevailing response requirements, such that phenmetrazine efficacy was greatest when cocaine choice was maintained by relatively low unit cocaine doses. These results suggest that efficacy of pharmacotherapies to modulate cocaine use can be influenced by behavioral contingencies of cocaine availability. Agonist medications may be most effective under contingencies that engender choice of relatively low cocaine doses.
Authors:
Matthew L Banks; Bruce E Blough; S Stevens Negus
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-09-21
Journal Detail:
Title:  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology     Volume:  38     ISSN:  1740-634X     ISO Abbreviation:  Neuropsychopharmacology     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-16     Completed Date:  2013-10-17     Revised Date:  2014-04-24    
Medline Journal Info:
Nlm Unique ID:  8904907     Medline TA:  Neuropsychopharmacology     Country:  England    
Other Details:
Languages:  eng     Pagination:  395-404     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Depressants / administration & dosage
Choice Behavior / drug effects*,  physiology
Cocaine / administration & dosage*
Dose-Response Relationship, Drug
Eating / drug effects*,  physiology,  psychology*
Macaca mulatta
Male
Phenmetrazine / administration & dosage*
Reinforcement Schedule*
Self Administration
Treatment Outcome
Grant Support
ID/Acronym/Agency:
R01 DA012970/DA/NIDA NIH HHS; R01 DA026946/DA/NIDA NIH HHS; R01-DA012790/DA/NIDA NIH HHS; R01-DA26946/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Appetite Depressants; I5Y540LHVR/Cocaine; XA501VL3VR/Phenmetrazine
Comments/Corrections

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