| Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis. | |
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MedLine Citation:
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PMID: 20638385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We reported a novel interaction between Beclin 1, a key regulator of autophagy, and survivin, a member of the inhibitor of apoptosis protein family. We found that knock-down of Beclin 1 down-regulated survivin protein, and the turnover rate of survivin was increased when Beclin 1 expression was silenced. Knock-down of Beclin 1 sensitized glioma cells to TRAIL-induced apoptosis, and introduction of survivin antagonized the sensitizing effect, suggesting that down-regulation of survivin mediates the enhanced sensitivity to TRAIL-induced apoptosis. These results demonstrate a novel interaction between Beclin 1 and survivin, and may provide a potential mechanism underlying the cross-talk between autophagy and apoptosis. |
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Authors:
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Ting-Kuang Niu; Yan Cheng; Xingcong Ren; Jin-Ming Yang |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-07-16 |
Journal Detail:
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Title: FEBS letters Volume: 584 ISSN: 1873-3468 ISO Abbreviation: FEBS Lett. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-16 Completed Date: 2010-09-03 Revised Date: 2011-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 3519-24 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Pharmacology and The Penn State Cancer Institute, The Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apoptosis
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drug effects,
physiology* Apoptosis Regulatory Proteins / antagonists & inhibitors, genetics, metabolism* Base Sequence Cell Line, Tumor DNA Primers / genetics Down-Regulation Gene Knockdown Techniques Glioma / drug therapy, metabolism*, pathology* Humans Membrane Proteins / antagonists & inhibitors, genetics, metabolism* Microtubule-Associated Proteins / genetics, metabolism* Protein Interaction Mapping RNA, Small Interfering / genetics Recombinant Proteins / metabolism, pharmacology TNF-Related Apoptosis-Inducing Ligand / metabolism*, pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA066077-12/CA/NCI NIH HHS; R01 CA135038-01A2/CA/NCI NIH HHS; R01 CA135038-02/CA/NCI NIH HHS; R01 CA135038-03/CA/NCI NIH HHS; R01CA 135038/CA/NCI NIH HHS; R01CA 66077/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apoptosis Regulatory Proteins; 0/BECN1 protein, human; 0/BIRC5 protein, human; 0/DNA Primers; 0/Membrane Proteins; 0/Microtubule-Associated Proteins; 0/RNA, Small Interfering; 0/Recombinant Proteins; 0/TNF-Related Apoptosis-Inducing Ligand; 0/TNFSF10 protein, human |
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