| Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy. | |
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MedLine Citation:
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PMID: 17921333 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Elevated wall stress by hypertension induces an adaptive myocardial hypertrophy via releasing prohypertrophic hormones such as angiotensin II. In this study, we investigated the involvement of bone morphogenetic protein-10 (BMP10) in hypertension-induced cardiac hypertrophy. Expression of BMP10 was increased in the hypertrophied ventricles from hypertensive rats. BMP10 localized on cell surface and at stretch-sensing Z disc of cardiomyocytes, where BMP10 interacted with a protein called titin-cap (Tcap). A rare variant of the human BMP10 gene, Thr326Ile, was found to be associated with hypertensive dilated cardiomyopathy. The variant BMP10 demonstrated decreased binding to Tcap and increased extracellular secretion. Conditioned medium from cells transfected with wild-type or variant BMP10 induced hypertrophy in rat neonatal cardiomyocytes, except that medium from variant BMP10-carrying cells showed an enhanced effect reflecting the increased secretion. These observations suggested that hypertension induced expression of prohypertrophic BMP10, and the hypertrophic effect of BMP10 was modulated, at least in part, by its binding to Tcap at the Z disc. |
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Authors:
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Noritsugu Nakano; Hisae Hori; Minako Abe; Hiroki Shibata; Takuro Arimura; Taishi Sasaoka; Motoji Sawabe; Kouji Chida; Tomio Arai; Ken-ichi Nakahara; Toru Kubo; Ken Sugimoto; Tomohiro Katsuya; Toshio Ogihara; Yoshinori Doi; Tohru Izumi; Akinori Kimura |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-10-05 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 293 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-06 Completed Date: 2008-01-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H3396-403 Citation Subset: IM |
Affiliation:
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Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kanda-surugadai, Chiyoda-ku, Tokyo 101-0062, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Autocrine Communication* Bone Morphogenetic Proteins / genetics, metabolism* Cardiomegaly / etiology, metabolism*, pathology Cell Size Cells, Cultured Culture Media, Conditioned / metabolism Disease Models, Animal Disease Progression Humans Hypertension / complications*, etiology, metabolism, pathology Muscle Proteins / genetics, metabolism* Mutation Myocytes, Cardiac / metabolism*, pathology Polymorphism, Single-Stranded Conformational Protein Binding Rats Rats, Inbred SHR Rats, Sprague-Dawley Sodium Chloride, Dietary Time Factors Transfection Up-Regulation |
| Chemical | |
Reg. No./Substance:
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0/Bone Morphogenetic Proteins; 0/Culture Media, Conditioned; 0/Muscle Proteins; 0/Sodium Chloride, Dietary; 0/TCAP protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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