Document Detail


Interaction of allergens, major histocompatibility complex molecules, and T cell receptors: a 'ménage à trois' that opens new avenues for therapeutic intervention in type I allergy.
MedLine Citation:
PMID:  21447957     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
T cells are major players in the initiation and perpetuation of the allergic immune response. In this review, we summarize the current knowledge on allergen recognition by T lymphocytes and address the components of the trimeric recognition complex: T cell receptors, major histocompatibility complex molecules, and allergen-derived peptides. Furthermore, possible implications of this scientific background for future therapeutic developments are discussed.
Authors:
Beatrice Jahn-Schmid; Winfried F Pickl; Barbara Bohle
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2011-03-29
Journal Detail:
Title:  International archives of allergy and immunology     Volume:  156     ISSN:  1423-0097     ISO Abbreviation:  Int. Arch. Allergy Immunol.     Publication Date:  2011  
Date Detail:
Created Date:  2011-08-23     Completed Date:  2011-10-26     Revised Date:  2012-04-10    
Medline Journal Info:
Nlm Unique ID:  9211652     Medline TA:  Int Arch Allergy Immunol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  27-42     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Affiliation:
Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. beatrice.jahn-schmid @ meduniwien.ac.at
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MeSH Terms
Descriptor/Qualifier:
Allergens / immunology*
Animals
CD4-Positive T-Lymphocytes / immunology*
Humans
Hypersensitivity, Immediate / immunology*
Major Histocompatibility Complex / immunology*,  physiology
Receptors, Antigen, T-Cell / immunology,  metabolism*
Grant Support
ID/Acronym/Agency:
P 20011-B13//Austrian Science Fund FWF
Chemical
Reg. No./Substance:
0/Allergens; 0/Receptors, Antigen, T-Cell

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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