Document Detail

Inter-relationships between sodium and potassium intake and the blood pressure effects of ACTH in sheep.
MedLine Citation:
PMID:  6099379     Owner:  NLM     Status:  MEDLINE    
These studies examine the effect of sodium (Na) and potassium (K) intake on the pressor and metabolic actions of ACTH (20 micrograms/kg/day) in sheep. After 21 days on each of five regimens in which Na and K intake varied from 0 to 100 mmol/day, no simple relationship between Na and K intake and blood pressure was found. After five days of ACTH treatment, mean arterial pressure (MAP) rose + 5 mmHg in sheep on 0 mmol Na, 0 mmol K (expressed as 0 Na 0 K); + 13 mmHg on 10 Na 100 K; + 5 mmHg on 0 Na 100 K; + 20 mmHg on 100 Na 0 K and + 24 mmHg on 100 Na 100 K. Plasma [K] was unchanged by ACTH on 0 Na 0 K but fell in sheep on the other electrolyte regimens. Water intake increased with ACTH on all regimens except 100 Na 0 K. Blood aldosterone concentration was high in sheep maintained on 0 Na regimens but lower after five days of ACTH treatment in all groups. Blood cortisol and corticosterone concentrations increased with ACTH on all regimens studied.
T J Humphrey; J S Fan; J P Coghlan; D A Denton; B A Scoggins; K W Stewart; J A Whitworth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  1     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1985-04-26     Completed Date:  1985-04-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  19-26     Citation Subset:  IM    
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MeSH Terms
Adrenocorticotropic Hormone / pharmacology*
Blood Pressure / drug effects*
Body Water / metabolism
Heart Rate / drug effects
Hypertension / chemically induced
Potassium / administration & dosage*,  metabolism
Sodium / administration & dosage*,  metabolism
Reg. No./Substance:
7440-09-7/Potassium; 7440-23-5/Sodium; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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