Document Detail

Inter-observer variability in histopathological assessment of liver biopsies taken in a pediatric open label therapeutic program for chronic HBV infection treatment.
MedLine Citation:
PMID:  16586539     Owner:  NLM     Status:  MEDLINE    
AIM: To our knowledge, the inter-observer variability of the liver biopsy findings in HBV-infected children have not been studied as yet. Hence, we aimed to compare different pathologist's assessment of grading and staging in liver biopsies obtained from children prior to interferon treatment.
METHODS: We collected 920 biopsies from 11 medical centers. The biopsies were independently reviewed by 6 pathologists from academic centers who assessed Batts-Ludwig score for grading and staging. Satisfactory agreement among observers was defined as at least 60% of observers having the same opinion. Satisfactory dispersion between maximal and minimal score for the same biopsy specimen was defined as a maximum 1 point.
RESULTS: Satisfactory inter-observer agreement for grading was obtained in 51.6% and for staging in 75.7% of biopsies. Satisfactory dispersion for grading scores was observed in 44.5% and for staging in 72.7% of cases.
CONCLUSION: Our study demonstrates that: (1) pathologists differ in their assessment of grading and staging of liver biopsies; (2) inter-observer variability for staging is lower than that for grading; and (3) regardless of the inter-observer variability of assessments, the majority of children with chronic HBV infection have mild to moderate inflammation and mild to moderate fibrosis.
Marek Woynarowski; Joanna Cielecka-Kuszyk; Andrzej Kałuzyński; Aleksandra Omulecka; Maria Sobaniec-Łotowska; Julian Stolarczyk; Wojciech Szczepański
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  12     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-04-04     Completed Date:  2006-08-29     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  1713-7     Citation Subset:  IM    
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MeSH Terms
Antiviral Agents / therapeutic use
Child, Preschool
Disease Progression
Hepatitis B, Chronic / drug therapy*,  epidemiology,  pathology*
Inflammation / pathology
Interferons / therapeutic use
Liver / pathology
Liver Cirrhosis / pathology
Observer Variation
Reproducibility of Results
Severity of Illness Index
Reg. No./Substance:
0/Antiviral Agents; 9008-11-1/Interferons

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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