Document Detail

Inter-method differences in the measurement of some specific plasma proteins: commutability of control materials.
MedLine Citation:
PMID:  8704033     Owner:  NLM     Status:  MEDLINE    
We compared the inter-method differences shown by control materials and by patients' sera for the measurement of some plasma proteins in the same pair of analytical systems. Sets of 100 to 110 samples of patients' sera and of 18-19 control materials, including the recently available CRM 470, were assayed with up to five automatic analytical systems, in two different experiments. About 5500 values were produced and assessed statistically. Materials (either patients' sera or control materials) were considered non-commutable (i.e. exhibiting significantly different inter-method behaviour) when their distance from the regression line in a stated pair of methods exceeded 3 standard deviations. According to this criterion, less than 1.5% of the patients' sera, and an even lower proportion of control materials were non-commutable. However, the inter-method behaviour of control materials was usually slightly different from that of patients' sera. Some systematic inter-method difference in the measurements on patients' sera may therefore exist, even though inter-method equivalence has been demonstrated with control materials.
L Arcangeli; P Cueroni; C Franzini; G Galletta; A Moschini; L Scapellato
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies     Volume:  34     ISSN:  0939-4974     ISO Abbreviation:  Eur J Clin Chem Clin Biochem     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-09-12     Completed Date:  1996-09-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9105775     Medline TA:  Eur J Clin Chem Clin Biochem     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  37-42     Citation Subset:  IM    
Laboratorio Analisi, Ospedale Caduti Bollatesi, Bollate (Milano), Italy.
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MeSH Terms
Blood Chemical Analysis / methods*
Blood Proteins / analysis*
Immunoglobulins / blood
Reference Values
Transferrin / analysis
Reg. No./Substance:
0/Blood Proteins; 0/Immunoglobulins; 11096-37-0/Transferrin

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