| Inter-individual differences in trait negative affect moderate cortisol's effects on memory formation: preliminary findings from two studies. | |
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MedLine Citation:
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PMID: 21955834 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute emotional arousal moderates the effects of cortisol on memory. However, it is currently unknown how stable inter-individual differences (i.e., traits) moderate cortisol's effects on memory. In two studies using within-subjects designs - 31 healthy males in Study 1 and 42 healthy subjects (22 female) in Study 2 - we measured trait negative affect (NA) and presented emotional and neutral pictures. In Study 1, we manipulated endogenous cortisol levels using a speech stressor following encoding. In Study 2, using a randomized placebo-controlled design, we pharmacologically manipulated cortisol levels prior to encoding (0.1mg/kg hydrocortisone vs. saline infused over 30min). Free recall for pictures was subsequently assessed. Trait NA repeatedly moderated the relationship between cortisol and memory formation. Findings suggested the speculative conclusion that the direction of effects may vary by sex. In males, cortisol was related to memory facilitation in subjects with lower Trait NA. Conversely, females with higher Trait NA showed greater cortisol-related increases in memory. Trait NA may be a stable inter-individual difference predicting neurocognitive effects of cortisol during stressors. |
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Authors:
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Heather C Abercrombie; Michelle M Wirth; Roxanne M Hoks |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2011-09-28 |
Journal Detail:
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Title: Psychoneuroendocrinology Volume: 37 ISSN: 1873-3360 ISO Abbreviation: Psychoneuroendocrinology Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-03-21 Completed Date: 2012-07-27 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 7612148 Medline TA: Psychoneuroendocrinology Country: England |
Other Details:
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Languages: eng Pagination: 693-701 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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University of Wisconsin, School of Medicine and Public Health, Department of Psychiatry, Madison, WI 53719, USA. hcabercr@wisc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Affect / drug effects*, physiology Arousal / drug effects Female Humans Hydrocortisone / administration & dosage*, analysis, blood Individuality Male Mental Recall / drug effects* Saliva / chemistry Sex Factors Stress, Psychological / blood, drug therapy*, psychology Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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1K08MH07415-012/MH/NIMH NIH HHS; 1UL1RR025011/RR/NCRR NIH HHS; K08 MH074715/MH/NIMH NIH HHS; K08 MH074715-05/MH/NIMH NIH HHS; R01 MH094478/MH/NIMH NIH HHS; T32 MH018931-19/MH/NIMH NIH HHS; T32MH18931/MH/NIMH NIH HHS; UL1 RR025011-02/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-23-7/Hydrocortisone |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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