| Inter-eye difference in diabetic macular edema after unilateral intravitreal injection of triamcinolone acetonide. | |
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MedLine Citation:
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PMID: 15629288 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To report on visual outcome of patients receiving intravitreal triamcinolone acetonide for treatment of diffuse diabetic macular edema. DESIGN: Prospective, comparative clinical interventional study. METHODS: Setting: Institutional. patient population: The study included 25 consecutive patients (50 eyes) with bilateral diabetic macular edema. Intervention procedure: Unilateral intravitreal injection of about 20 mg triamcinolone acetonide into the eye (study group) more severely affected by diabetic maculopathy. The contralateral eyes served as control group. Mean follow-up was 7.1 +/- 4.1 months. MAIN OUTCOME MEASURE: Visual acuity, intraocular pressure. RESULTS: In the study group, visual acuity increased significantly (P < or = .001) by 3.0 +/- 2.6 Snellen lines to a peak at two to six months after the injection, and decreased significantly (P = .001) towards the end of follow up. At the end of follow-up, visual acuity was higher, not significantly (P = .18) higher, than at baseline. An increase in visual acuity was found in 23 eyes (92%). In the control group, differences between visual acuity at baseline and at any of the re-examinations during follow-up were not significant (P > .10). In an intra-individual inter-eye comparison, gain in visual acuity was significantly (P < .05) higher in the injected eyes, for the measurements obtained up to four months after injection. CONCLUSIONS: Intravitreal triamcinolone acetonide may temporarily increase visual acuity in eyes with diabetic macular edema. |
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Authors:
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Jost B Jonas; Björn Harder; Bernd A Kamppeter |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: American journal of ophthalmology Volume: 138 ISSN: 0002-9394 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2005-01-04 Completed Date: 2005-01-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 970-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Ophthalmology, Faculty of Clinical Medicine, Mannheim of the Ruprecht-Varls University, Heidelberg, Germany. Jost.Jonas@ma.augen.uni-heidelberg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Diabetic Retinopathy / drug therapy* Glucocorticoids / administration & dosage, therapeutic use* Humans Injections Intraocular Pressure Macular Edema / drug therapy* Middle Aged Pilot Projects Prospective Studies Triamcinolone Acetonide / administration & dosage, therapeutic use* Visual Acuity / drug effects Vitreous Body |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 76-25-5/Triamcinolone Acetonide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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