Document Detail

Inter-eye difference in diabetic macular edema after unilateral intravitreal injection of triamcinolone acetonide.
MedLine Citation:
PMID:  15629288     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To report on visual outcome of patients receiving intravitreal triamcinolone acetonide for treatment of diffuse diabetic macular edema.
DESIGN: Prospective, comparative clinical interventional study.
SETTING: Institutional. patient population: The study included 25 consecutive patients (50 eyes) with bilateral diabetic macular edema. Intervention procedure: Unilateral intravitreal injection of about 20 mg triamcinolone acetonide into the eye (study group) more severely affected by diabetic maculopathy. The contralateral eyes served as control group. Mean follow-up was 7.1 +/- 4.1 months.
MAIN OUTCOME MEASURE: Visual acuity, intraocular pressure.
RESULTS: In the study group, visual acuity increased significantly (P < or = .001) by 3.0 +/- 2.6 Snellen lines to a peak at two to six months after the injection, and decreased significantly (P = .001) towards the end of follow up. At the end of follow-up, visual acuity was higher, not significantly (P = .18) higher, than at baseline. An increase in visual acuity was found in 23 eyes (92%). In the control group, differences between visual acuity at baseline and at any of the re-examinations during follow-up were not significant (P > .10). In an intra-individual inter-eye comparison, gain in visual acuity was significantly (P < .05) higher in the injected eyes, for the measurements obtained up to four months after injection.
CONCLUSIONS: Intravitreal triamcinolone acetonide may temporarily increase visual acuity in eyes with diabetic macular edema.
Jost B Jonas; Björn Harder; Bernd A Kamppeter
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of ophthalmology     Volume:  138     ISSN:  0002-9394     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-01-04     Completed Date:  2005-01-18     Revised Date:  2014-07-29    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  970-7     Citation Subset:  AIM; IM    
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MeSH Terms
Aged, 80 and over
Diabetic Retinopathy / drug therapy*
Glucocorticoids / administration & dosage,  therapeutic use*
Intraocular Pressure
Macular Edema / drug therapy*
Middle Aged
Pilot Projects
Prospective Studies
Triamcinolone Acetonide / administration & dosage,  therapeutic use*
Visual Acuity / drug effects
Vitreous Body
Reg. No./Substance:
0/Glucocorticoids; F446C597KA/Triamcinolone Acetonide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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