| Inter-subject correlation exists between morphological metrics of cerebral blood flow velocity and intracranial pressure pulses. | |
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MedLine Citation:
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PMID: 21136207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The prototypical intracranial pressure (ICP) pulse morphology has been well known to be triphasic. Several studies suggest that the morphology of ICP pulse reflects the physiological and pathophysiological conditions of the intracranial dynamics. Recently, there has been a renaissance of studying ICP pulse using new ICP signal processing technologies in various clinical contexts. Cerebral blood flow velocity (CBFV) pulse is another important pulsatile signal originated from the complex circulatory systems of cerebral blood flow. However, CBFV pulse morphology has not been well studied mainly due to the noise level and lack of signal processing techniques. METHODS: Our group recently developed a technique called the morphological clustering and analysis of intracranial pressure that can extract a comprehensive set of pulse morphological metrics. We extend this algorithm to extract various morphological metrics from ICP and CBFV pulses that were simultaneously recorded from 47 brain injury patients and investigate the mutual correlation between those metrics utilizing the robust percentage bend correlation analysis. RESULTS: Our results show that CBFV pulses are also triphasic as ICP pulses and 15.2% of 128 pulse morphological metrics extracted from ICP and CBFV pulses are highly correlated (P < 0.01) in an inter-subject fashion. In addition, mean ICP does not correlate (P = 0.45) with the pulsatility index of CBFV pulses but correlates (P < 0.05) with several novel CBFV pulse morphological metrics such as the time interval between the onset of CBFV pulses and ECG QRS peak. CONCLUSIONS: Our results suggest that characterizing CBFV pulse morphology is clinically important because it may offer a potential noninvasive alternative to assess various aspects of ICP such as mean ICP. |
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Authors:
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Sunghan Kim; Xiao Hu; David McArthur; Robert Hamilton; Marvin Bergsneider; Thomas Glenn; Neil Martin; Paul Vespa |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-12-07 |
Journal Detail:
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Title: Neurocritical care Volume: 14 ISSN: 1556-0961 ISO Abbreviation: Neurocrit Care Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-22 Completed Date: 2011-07-27 Revised Date: 2012-04-04 |
Medline Journal Info:
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Nlm Unique ID: 101156086 Medline TA: Neurocrit Care Country: United States |
Other Details:
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Languages: eng Pagination: 229-37 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Neural Systems and Dynamics Laboratory, David Geffen School of Medicine at University of California, 10833 Le Conte, NPI 18-240, Los Angeles, CA 90095, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Flow Velocity / physiology* Brain Injuries / physiopathology* Cerebrovascular Circulation / physiology* Female Humans Hydrocephalus, Normal Pressure / physiopathology Intensive Care Intracranial Pressure / physiology* Male Middle Aged Models, Cardiovascular* Pulsatile Flow / physiology Retrospective Studies Subarachnoid Hemorrhage / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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NS054881/NS/NINDS NIH HHS; NS059797/NS/NINDS NIH HHS; NS066008/NS/NINDS NIH HHS; R01 NS066008-02/NS/NINDS NIH HHS; R01 NS066008-03/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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