Document Detail


Intentions to use preexposure prophylaxis among current phase 2B preventive HIV-1 vaccine efficacy trial participants.
MedLine Citation:
PMID:  23614998     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In November 2010, the iPrEx study reported that preexposure prophylaxis (PrEP) with daily tenofovir disoproxil fumarate/emtricitabine reduced HIV infections by 44% among men who have sex with men and subsequent trials corroborated efficacy among heterosexual men and women. During regularly scheduled follow-up visits from January to March 2011, participants in an ongoing phase 2b vaccine efficacy trial completed an anonymous Web survey about PrEP. Among 376 respondents, 17% reported they were very likely to use PrEP in the next year. Nonwhite participants were more likely to use PrEP. Among those with some level of interest, intent to use PrEP was greatest if the drug were available through the clinical trial or health insurance. Most (91%) believed taking PrEP would not change their willingness to stay in the vaccine trial and few thought it would affect recruitment. As key stakeholders, currently enrolled trial participants can offer vital input about emerging prevention technologies that may affect the design of future HIV vaccine and nonvaccine prevention trials.
Authors:
Jonathan D Fuchs; Magdalena E Sobieszczyk; Tamra Madenwald; Doug Grove; Shelly T Karuna; Michele Andrasik; Adam Sherwat; Gail Broder; Kenneth Mayer; Beryl Koblin; Scott Hammer;
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  63     ISSN:  1944-7884     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-13     Completed Date:  2013-08-29     Revised Date:  2014-08-19    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  259-62     Citation Subset:  IM; X    
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MeSH Terms
Descriptor/Qualifier:
AIDS Vaccines / therapeutic use*
Adenine / analogs & derivatives*,  therapeutic use
Adolescent
Adult
Anti-HIV Agents / therapeutic use*
Deoxycytidine / analogs & derivatives*,  therapeutic use
HIV Infections / drug therapy,  prevention & control*
Heterosexuality
Homosexuality, Male
Humans
Intention
Male
Middle Aged
Organophosphonates / therapeutic use*
Questionnaires
Research Design
Young Adult
Grant Support
ID/Acronym/Agency:
AI068614/AI/NIAID NIH HHS; AI068614 AI068635/AI/NIAID NIH HHS; U01 AI069496/AI/NIAID NIH HHS; UL1RR024156/RR/NCRR NIH HHS; UM1 AI069496/AI/NIAID NIH HHS; UM1AI069480-05/AI/NIAID NIH HHS; UO1AI069412/AI/NIAID NIH HHS; UO1AI069496/AI/NIAID NIH HHS; UO1AI69470/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/AIDS Vaccines; 0/Anti-HIV Agents; 0/Organophosphonates; 0/emtricitabine; 0/tenofovir disoproxil; 0W860991D6/Deoxycytidine; JAC85A2161/Adenine
Investigator
Investigator/Affiliation:
Donald Poretz / ; Mark Mulligan / ; Sri Edupunganti / ; Barney Graham / ; Julie Ledgerwood / ; Paul Goepfert / ; Lindsey Baden / ; Doug Krakower / ; Richard Novak / ; Michael Lederman / ; Benigno Rodriguez / ; Mamta Jain / ; Thomas Campbell / ; Hana El Sahly / ; Stephen Brown / ; Spyros Kalams / ; Demetre Daskalakis / ; Edwin DeJesus / ; Ian Frank / ; Michael Keefer / ; Susan Buchbinder / ; Darpun Sachdev / ; Juliana McElrath / ; Janine Maenza / ; Soyon Im / ; Jim Maynard / ; Niles Eaton / ; Steve Wakefield / ; Shelly Mahilum / ; Peter Gilbert / ; Jim Kublin / ; Larry Corey / ; Elizabeth Adams / ; Rick Church / ; Richard Trevino / ; Jason Roberts / ; Coco Alinsug /
Comments/Corrections

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