Document Detail


Intentional etanercept use during pregnancy for maintenance of remission in rheumatoid arthritis.
MedLine Citation:
PMID:  21269575     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Rheumatoid arthritis is associated with an increased risk of adverse pregnancy outcomes. TNF inhibitors are effective in the treatment of signs and symptoms of the disease although their safety during pregnancy is debated.
METHODS: Two cases of women with rheumatoid arthritis in complete remission of the disease with etanercept who decided to continue the therapy throughout their pregnancy are presented. A longitudinal evaluation of the disease activity showed a satisfactory control and good pregnancy outcomes were obtained. A flare of the disease after delivery was not observed.
CONCLUSIONS: Etanercept seems to be safe during pregnancy and lactation. A good control of the activity of the disease was reported throughout the pregnancy and during puerperium, when a reactivation of rheumatoid arthritis is often observed.
Authors:
Crescenzio Scioscia; Marco Scioscia; Maria Grazia Anelli; Emanuela Praino; Stefano Bettocchi; Giovanni Lapadula
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2011-02-23
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  29     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    2011 Jan-Feb
Date Detail:
Created Date:  2011-02-24     Completed Date:  2011-05-03     Revised Date:  2012-08-27    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  93-5     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine and Public Health, University of Bari, Bari, Italy. ezio.scioscia@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Antirheumatic Agents / therapeutic use*
Arthritis, Rheumatoid / drug therapy*,  physiopathology
Female
Health Status
Humans
Immunoglobulin G / therapeutic use*
Infant, Newborn
Lactation / drug effects
Live Birth*
Pregnancy
Pregnancy Complications / drug therapy*
Receptors, Tumor Necrosis Factor / therapeutic use*
Remission Induction
Severity of Illness Index
Young Adult
Chemical
Reg. No./Substance:
0/Antirheumatic Agents; 0/Immunoglobulin G; 0/Receptors, Tumor Necrosis Factor; 185243-69-0/TNFR-Fc fusion protein
Comments/Corrections
Comment In:
Clin Exp Rheumatol. 2012 May-Jun;30(3):453   [PMID:  22704593 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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