Document Detail

Intensive swimming exercise-induced oxidative stress and reproductive dysfunction in male wistar rats: protective role of alpha-tocopherol succinate.
MedLine Citation:
PMID:  15064426     Owner:  NLM     Status:  MEDLINE    
In the present study, 30 male rats (age 3 mos, Wt 128.6 +/- 3.7 g) were randomly divided into Control group (CG), Experimental group (EG), and Supplemented group (SG), 10 per group. An exercise protocol (3 hrs swimming per day, 5 days a week for 4 weeks) was followed in EG and SG, with no exercise in CG. In SG, alpha-tocopherol succinate was injected sub-cutaneously at a dose of 50 mg x kg(- 1) per body weight per day. After 4 weeks of exercise, significant diminutions (p < 0.05) were noted in somatic indices of testes and accessory sex organs; seminiferous tubuler diameter (STD); testicular (delta (5), 3 beta-hydroxysteroid dehydrogenase delta(5), 3 beta-HSD), 17 beta-hydroxysteroid dehydrogenase (17 beta-HSD) activities; plasma levels of testosterone (T), luteinizing hormone (LH); preleptotine spermatocytes (pLSc), mid-pachytene spermatocytes (mPSc), and Stage 7 spermatids (7 Sd); testicular alpha-tocopherol and glutathione (GSH) content; superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and glutathione-s-transferase (GST) activities in EG when compared to CG. Moreover, a significant elevation (p < 0.05) in malondialdehyde (MDA) was found in testes of EG compared to CG. No significant alteration was noted in body weight among the groups. Co-administration of alpha-tocopherol succinate restored the above parameters. Intensive swimming exercise-induced oxidative stress causes dysfunction in the male reproductive system, which can be protected by alpha-tocopherol succinate.
Indranil Manna; Kuladip Jana; Prabhat Kumar Samanta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of applied physiology = Revue canadienne de physiologie appliquée     Volume:  29     ISSN:  1066-7814     ISO Abbreviation:  Can J Appl Physiol     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-05     Completed Date:  2004-11-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9306274     Medline TA:  Can J Appl Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  172-85     Citation Subset:  IM    
Human Performance Lab, Sports Authority of India, New Delhi, India.
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MeSH Terms
Antioxidants / administration & dosage*
Oxidative Stress / drug effects
Physical Conditioning, Animal / physiology*
Rats, Wistar
Swimming / physiology*
Testis / anatomy & histology,  drug effects*,  metabolism
Testosterone / blood,  deficiency
Vitamin E / administration & dosage*,  analogs & derivatives*
Reg. No./Substance:
0/Antioxidants; 1406-18-4/Vitamin E; 1406-66-2/Tocopherols; 58-22-0/Testosterone

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