Document Detail


Intensive statin therapy in coronary artery disease: is lower cholesterol better and safe?
MedLine Citation:
PMID:  19371188     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Primary- and secondary-prevention trials involving subjects with or at risk for coronary artery disease have previously demonstrated a beneficial effect of conventional-dose statin therapy. Recent trials of high-dose statin therapy in subjects with stable coronary disease or acute coronary syndromes have yielded conflicting results. The aim of this narrative article is to provide a critical and up-to-date summary of the findings of clinical trials of intensive statin therapy, including a brief overview of the safety and efficacy of such treatments.
Authors:
Sreenivasa R K Seshasai; Kausik K Ray
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Future cardiology     Volume:  5     ISSN:  1744-8298     ISO Abbreviation:  Future Cardiol     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-04-17     Completed Date:  2009-07-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101239345     Medline TA:  Future Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  129-39     Citation Subset:  IM    
Affiliation:
Molecular Epidemiology Unit, Strangeways Research Laboratory, Worts Causeway, Cambridge, CB1 8RN, UK. srk36@medschl.cam.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Cholesterol / blood*
Coronary Artery Disease / blood,  drug therapy*
Dose-Response Relationship, Drug
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage,  therapeutic use*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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