| Intensive resistance exercise induces lymphocyte apoptosis via cortisol and glucocorticoid-receptor dependent pathways. | |
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MedLine Citation:
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PMID: 21393471 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Intensive endurance exercise is known to induce lymphocyte apoptosis which might affect immune function. Less is known about the effects of resistance exercise on apoptosis and the underlying mechanisms. In this study, subjects performed an intensive resistance test (IRT) and a moderate resistance test (MRT) and lymphocyte apoptosis, apoptosis related parameters and underlying mechanisms were investigated. IRT induced a significant increase of lymphocyte apoptosis 3h after exercise which was accompanied by a significant decrease of MMP, a reduction of Bcl-2 and an up-regulation of CD95R. Blood lactate, IL-6, CRP and cortisol increased significantly 3h after IRT. A significant correlation was observed between the increase of apoptosis and cortisol levels 3h after IRT. Incubation of freshly isolated lymphocytes in IRT serum indicated an important role of serum correlates for apoptosis induction. Selective incubation of lymphocytes in concentrations of selected serum parameters corresponding to levels found post in IRT serum demonstrated a major role for cortisol in apoptosis induction. This result was confirmed by attenutation of apoptosis after addition of mifepristone before incubation in IRT serum. In summary, resistance exercise induced lymphocyte apoptosis in an intensity dependent way. Furthermore, cortisol signalling via glucocorticoid receptors might be an important mechanism for lymphocyte apoptosis after resistance exercise. |
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Authors:
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Karsten Krüger; Stephan Agnischock; Anja Lechtermann; Shuchita Tiwari; Manish Mishra; Christian Pilat; Achim Wagner; Corinna Tweddell; Imke Gramlich; Frank C Mooren |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-10 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Department of Sports Medicine, Justus-Liebig-University, Giessen. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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