| Intensive plasma exchange for severe autoimmune hemolytic anemia in a four-month-old infant. | |
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MedLine Citation:
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PMID: 10611631 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report the smallest infant (7.5 kg) to receive intensive plasma exchange (52 PEs) therapy as treatment of autoimmune hemolytic anemia (AIHA). PE temporarily reduces circulating autoantibody levels and can be an effective adjunctive therapy with corticosteroids and cytotoxic drugs or other immuno-suppressants. Although his clinical course was prolonged and complicated by cytomegalovirus infection with spontaneous perforation of his colon, his recovery was complete. He has remained healthy for more than 2 years. Because of his small size, calcium gluconate was added to replacement fluids and calcium levels closely monitored. The apheresis machine and tubing were routinely primed with red blood cells and FFP substituted for 5% human albumin during the second half of all procedures to maintain adequate levels of procoagulant. Our experience suggests that intensive PE is helpful in controlling severe AIHA and should be considered even for very small patients. |
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Authors:
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L J McCarthy; C F Danielson; C Fernandez; E Skipworth; C A Limiac; T Prahlow; J Goldman |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of clinical apheresis Volume: 14 ISSN: 0733-2459 ISO Abbreviation: J Clin Apher Publication Date: 1999 |
Date Detail:
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Created Date: 2000-02-04 Completed Date: 2000-02-04 Revised Date: 2005-07-26 |
Medline Journal Info:
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Nlm Unique ID: 8216305 Medline TA: J Clin Apher Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 190-2 Citation Subset: IM |
Copyright Information:
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Copyright 1999 Wiley-Liss, Inc. |
Affiliation:
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Indiana University Medical Center, Indianapolis, Indiana 46202, USA. lmmcarth@iupui.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use Anemia, Hemolytic, Autoimmune / complications, drug therapy, surgery, therapy* Autoimmune Diseases / complications, drug therapy, surgery, therapy* Calcium Gluconate / therapeutic use Combined Modality Therapy Cytomegalovirus Infections / complications Humans Immunoglobulins, Intravenous / therapeutic use Immunosuppressive Agents / adverse effects, therapeutic use Infant Intestinal Perforation / complications Male Methylprednisolone / therapeutic use Plasma Exchange* Sigmoid Diseases / complications Splenectomy |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Immunoglobulins, Intravenous; 0/Immunosuppressive Agents; 299-28-5/Calcium Gluconate; 83-43-2/Methylprednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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