Document Detail

Intensive lipid-lowering therapy ameliorates novel calcification markers and GSM score in patients with carotid stenosis.
MedLine Citation:
PMID:  18395477     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES/DESIGN: Carotid plaque echogenicity quantified by the Gray-Scale Median (GSM) score has been associated with plaque vulnerability. The aim of this study was to assess whether intensive lipid-lowering treatment with atorvastatin in patients with carotid artery stenosis ameliorates novel vascular calcification inhibitors, such as osteopontin (OPN) and osteoprotegerin (OPG), and improves GSM score. METHODS: Ninety-seven patients with carotid stenosis (>40%), but without indication for intervention, were treated for 6 months with atorvastatin (10mg-80mg) to target LDL<100mg/dl. Fifty-two age-and sex-matched healthy individuals served as the control group. Blood samples and GSM were obtained at the beginning and after 6 months. RESULTS: Systolic blood pressure, hsCRP, fibrinogen, OPN and OPG levels differed significantly between patients with carotid stenosis and healthy controls at baseline (p<0.05). Atorvastatin treatment improved lipid profile and significantly reduced hsCRP (p=0.002), WBC count (p=0.041), OPN (p<0.001) and OPG levels (p<0.001). GSM score increased considerably after atorvastatin therapy (from 58.33+/-24.38 to 79.33+/-22.3; p<0.001) and that effect appeared related to OPN (p=0.001), OPG (p=0.013) and LDL (p=0.01) reduction. CONCLUSIONS: In patients with carotid stenosis, intensive lipid-lowering therapy with statins attenuates serum OPN and OPG levels and enhances carotid plaque echogenicity, outlining their beneficial effects on plaque stability.
N P E Kadoglou; T Gerasimidis; A Moumtzouoglou; A Kapelouzou; N Sailer; G Fotiadis; I Vitta; A Katinios; P Kougias; S Bandios; K Voliotis; P E Karayannacos; C D Liapis
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-18
Journal Detail:
Title:  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery     Volume:  35     ISSN:  1532-2165     ISO Abbreviation:  Eur J Vasc Endovasc Surg     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-19     Completed Date:  2008-06-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9512728     Medline TA:  Eur J Vasc Endovasc Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  661-8     Citation Subset:  IM    
Department of Vascular Surgery, Medical School, University of Athens, Greece.
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MeSH Terms
Biological Markers / blood
Blood Pressure
C-Reactive Protein / metabolism
Calcinosis / blood,  drug therapy*,  ultrasonography
Carotid Stenosis / blood,  drug therapy*,  ultrasonography
Fibrinogen / metabolism
Heptanoic Acids / therapeutic use*
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Leukocyte Count
Middle Aged
Osteopontin / blood*
Osteoprotegerin / blood*
Prospective Studies
Pyrroles / therapeutic use*
Severity of Illness Index
Treatment Outcome
Reg. No./Substance:
0/Biological Markers; 0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Osteoprotegerin; 0/Pyrroles; 0/TNFRSF11B protein, human; 106441-73-0/Osteopontin; 110862-48-1/atorvastatin; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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