| Intensive insulin treatment increases donor site wound protein synthesis in burn patients. | |
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MedLine Citation:
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PMID: 21236451 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In the treatment of burns, patients' own skin is the preferred material to cover burn wounds, resulting in the need to create a donor site wound. Enhancement of healing of the donor site wound would be beneficial in burn patients. Insulin, an anabolic agent, is used routinely to treat hyperglycemia after injury. We investigated whether intensive insulin treatment increases fractional synthesis rate (FSR) of the donor site wound protein and decreases the length of hospitalization normalized for total body surface area burned (LOS/TBSA). METHODS: FSR of the donor site wound protein was measured in pediatric patients randomized to control (n = 13) and insulin (n = 10) treatments. Depending on the postoperative day when the tracer study was done, studies were divided into "early" (days < 5) and "late" (days ≥ 5) periods. RESULTS: FSR of the donor site wound protein was greater in the insulin group at the "early" period of wound healing (control vs insulin, 8.2 ± 3.8 vs 13.1 ± 6.9% per day; P < .05); but not at the "late" (control vs insulin, 19.7 ± 4.6 vs 16.6 ± 4.0% per day; P > .05). Despite these differences, LOS/TBSA was not decreased in the insulin group. Correlation analyses demonstrated that, independent of the treatment regimen, FSR positively correlated (P < .05) with time after creation of the donor site and negatively correlated (P < .05) with LOS/TBSA. CONCLUSION: Insulin treatment increased FSR of the donor site wound protein in the early period of wound healing; FSR correlated with LOS/TBSA independent of the treatment regimen. |
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Authors:
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Demidmaa Tuvdendorj; Xiao-Jun Zhang; David L Chinkes; Asle Aarsland; Gabriela A Kulp; Marc G Jeschke; David N Herndon |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-01-14 |
Journal Detail:
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Title: Surgery Volume: 149 ISSN: 1532-7361 ISO Abbreviation: Surgery Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-16 Completed Date: 2011-06-01 Revised Date: 2011-10-14 |
Medline Journal Info:
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Nlm Unique ID: 0417347 Medline TA: Surgery Country: United States |
Other Details:
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Languages: eng Pagination: 512-8 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 Mosby, Inc. All rights reserved. |
Affiliation:
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Metabolism Unit, Shriners Hospital for Children, Galveston, TX 77550-1220, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Burns / surgery Child Child, Preschool Female Humans Hypoglycemic Agents / administration & dosage* Insulin / administration & dosage* Male Protein Biosynthesis / drug effects* Skin Transplantation* Wound Healing / drug effects* |
| Grant Support | |
ID/Acronym/Agency:
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H133A020102//PHS HHS; P50-GM60338/GM/NIGMS NIH HHS; R01 GM056687-13/GM/NIGMS NIH HHS; R01-GM56687/GM/NIGMS NIH HHS; T32-GM08256/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hypoglycemic Agents; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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