| Intensive cholesterol-lowering therapy improves large artery elasticity in acute myocardial infarction patients. | |
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MedLine Citation:
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PMID: 19784816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was aimed at probing the effects of intensive cholesterol-lowering therapy with simvastatin on the large artery elasticity of acute myocardial infarction patients. A total of 72 cases of acute myocardial infarction patients were divided into a normocholesterol group (n = 37) and a hypercholesterol group (n = 35) according to their serum low-density lipoprotein. All patients were given oral simvastatin 40 mg/day for 6 months, and their pulse-wave velocity (PWV) of different artery segments and ankle-brachial index (ABI) were measured before and after the therapy. The low-density lipoprotein cholesterol level in both groups decreased significantly (2.13 +/- 0.32 vs 1.56 +/- 0.28, 3.43 +/- 0.80 vs 2.28 +/- 0.47 mmol/l, P < 0.01). The PWV of each artery segment in both the normocholesterol group and the hypercholesterol group decreased significantly (P < 0.05). Pulse-wave velocity in the hypercholesterol group was lowered much more than that of the normocholesterol group (P < 0.05). There were no differences among each artery segment in each group. Ankle-brachial index increased significantly in both groups (1.12 +/- 0.16 to 1.22 +/- 0.12, P < 0.05 in the normocholesterol group, and 1.03 +/- 0.22 to 1.23 +/- 0.16, P < 0.01 in the hypercholesterol group), but ABI increased much more in the hypercholesterol group than in the normocholesterol group (0.21 + 0.15 vs 0.11 + 0.09 P = 0.02). Intensive cholesterol-lowering therapy with simvastatin for acute myocardial infarction patients can significantly improve their large artery elasticity and regress their atherosclerosis. Hypercholesterol patients benefit more from this therapy. |
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Authors:
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Xinwei Jia; Meng Wei; Xianghua Fu; Xinshun Gu; Weize Fan; Jing Zhang; Ling Xue |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article Date: 2009-09-27 |
Journal Detail:
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Title: Heart and vessels Volume: 24 ISSN: 1615-2573 ISO Abbreviation: Heart Vessels Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-09-28 Completed Date: 2009-12-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8511258 Medline TA: Heart Vessels Country: Japan |
Other Details:
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Languages: eng Pagination: 340-6 Citation Subset: IM |
Affiliation:
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Cardiovascular Department, Second Hospital of Hebei Medical University, Shijiazhuang, P.R. China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Aged Ankle / blood supply Arteries / drug effects*, physiopathology Atherosclerosis / blood, complications, drug therapy*, physiopathology Biological Markers / blood Blood Pressure Brachial Artery / drug effects, physiopathology Cholesterol / blood* Cholesterol, LDL / blood Elasticity Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage, therapeutic use* Hypercholesterolemia / blood, complications, drug therapy*, physiopathology Linear Models Male Middle Aged Myocardial Infarction / blood, complications, drug therapy*, physiopathology Pulsatile Flow Simvastatin / administration & dosage, therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cholesterol, LDL; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 57-88-5/Cholesterol; 79902-63-9/Simvastatin |
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