Document Detail

Intensive chemotherapeutic regimens against acute leukemia transiently suppress asthma symptoms but do not lead to long-term relief.
MedLine Citation:
PMID:  11127397     Owner:  NLM     Status:  MEDLINE    
In some very rare cases children suffer from a combination of asthma and a malignant disease. This study investigated whether intensive chemotherapy might have a positive effect on asthma in these special cases and whether asthma generally relapses after completion of chemotherapy. The authors monitored clinical outcome and lung function of 43 children with acute lymphoblastic leukemia and non-Hodgkin lymphoma who received chemotherapy at the University Children's Hospital of Greifswald between 1993 and 1998. Cytostatic chemotherapy was administered according to the German treatment protocols. Two of the 43 patients had asthma before leukemia was diagnosed. During the course of chemotherapy, asthma symptoms diminished promptly after beginning of chemotherapy but asthma was rediagnosed after completion of chemotherapy in both cases. The third patient developed asthmatic symptoms shortly after completion of chemotherapy for the first time. It can be stated that chemotherapy does not essentially cure asthma. Therefore, it seems mandatory to perform follow-up lung testings after chemotherapy, especially in patients with asthma.
S Weigel; S M Schmidt; T Bernig; S Mukodzi; J F Beck; E H Ballke; S K Wiersbitzky
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric hematology and oncology     Volume:  17     ISSN:  0888-0018     ISO Abbreviation:  Pediatr Hematol Oncol     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-13     Completed Date:  2001-02-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8700164     Medline TA:  Pediatr Hematol Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  659-65     Citation Subset:  IM    
University Children's Hospital, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.
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MeSH Terms
Antineoplastic Agents / therapeutic use*
Asthma / complications*,  drug therapy
Child, Preschool
Lymphoma, Non-Hodgkin / complications*,  drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*,  drug therapy
Respiratory Function Tests
Time Factors
Reg. No./Substance:
0/Antineoplastic Agents
Comment In:
Pediatr Hematol Oncol. 2001 Sep;18(6):421-2   [PMID:  11554239 ]

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