Document Detail

Intensive lipid-lowering therapy with rosuvastatin stabilizes lipid-rich coronary plaques. -Evaluation using dual-source computed tomography.-.
MedLine Citation:
PMID:  21821963     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Clinical studies using invasive modalities have reported that statin therapy stabilizes coronary plaque vulnerability. The serial changes of lipid-rich coronary plaques (LRCPs) during rosuvastatin treatment were evaluated non-invasively in patients with acute coronary syndrome (ACS) using dual-source computed tomography (DSCT).
METHODS AND RESULTS: A total of 11 consecutive ACS patients, and 13 LRCPs were serially evaluated on DSCT before and 24 weeks after rosuvastatin treatment. Compared with the baseline, there was no change in post-treatment minimal lumen diameter, lumen volume, or longitudinal length of LRCPs. By contrast, the ratio of lipid core volume to plaque volume significantly decreased from 48.0 ± 9.9% to 43.7 ± 10.6% (P=0.04), and plaque volume decreased from 144.5 ± 85.5 mm³ to 119.8 ± 78.0 mm³ (P=0.07). The remodeling index of target LRCPs significantly decreased from 1.16 ± 0.10 to 1.06 ± 0.12 (P=0.02). Percent reduction of plaque volume was significantly greater in patients with a lower ratio of low-density lipoprotein to high-density lipoprotein (L/H ratio ≤ 1.5) at follow-up than patients with higher L/H ratio (>1.5; median -31.7% vs. -6.8%, P=0.03).
CONCLUSIONS: Rosuvastatin therapy reduced the volume of lipid cores and LRCPs and increased the CT attenuation value of LRCPs. DSCT is an effective modality for the non-invasive evaluation of LRCPs in patients with ACS. ).
Tsunenari Soeda; Shiro Uemura; Satoshi Okayama; Rika Kawakami; Yu Sugawara; Hitoshi Nakagawa; Takaki Matsumoto; Ji-Hee Sung; Taku Nishida; Ayako Senoo; Satoshi Somekawa; Yukiji Takeda; Kenichi Ishigami; Hiroyuki Kawata; Manabu Horii; Yoshihiko Saito
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article     Date:  2011-08-06
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  75     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2011  
Date Detail:
Created Date:  2011-10-26     Completed Date:  2012-02-14     Revised Date:  2012-08-24    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2621-7     Citation Subset:  IM    
First Department of Internal Medicine, Nara Medical University.
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MeSH Terms
Acute Coronary Syndrome* / drug therapy,  metabolism,  radiography
Aged, 80 and over
Coronary Angiography*
Fluorobenzenes / administration & dosage*
Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage*
Lipid Metabolism / drug effects
Middle Aged
Plaque, Atherosclerotic* / drug therapy,  metabolism,  radiography
Pyrimidines / administration & dosage*
Sulfonamides / administration & dosage*
Tomography, X-Ray Computed*
Reg. No./Substance:
0/Fluorobenzenes; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrimidines; 0/Sulfonamides; 287714-41-4/rosuvastatin
Comment In:
Circ J. 2012 May 25;76(6):1535; author reply 1536   [PMID:  22453007 ]

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