Document Detail


Intensity-modulated radiotherapy significantly reduces xerostomia compared with conventional radiotherapy.
MedLine Citation:
PMID:  16965864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Xerostomia is a severe complication after radiotherapy for oropharyngeal cancer, as the salivary glands are in close proximity with the primary tumor. Intensity-modulated radiotherapy (IMRT) offers theoretical advantages for normal tissue sparing. A Phase II study was conducted to determine the value of IMRT for salivary output preservation compared with conventional radiotherapy (CRT). METHODS AND MATERIALS: A total of 56 patients with oropharyngeal cancer were prospectively evaluated. Of these, 30 patients were treated with IMRT and 26 with CRT. Stimulated parotid salivary flow was measured before, 6 weeks, and 6 months after treatment. A complication was defined as a stimulated parotid flow rate <25% of the preradiotherapy flow rate. RESULTS: The mean dose to the parotid glands was 48.1 Gy (SD 14 Gy) for CRT and 33.7 Gy (SD 10 Gy) for IMRT (p < 0.005). The mean parotid flow ratio 6 weeks and 6 months after treatment was respectively 41% and 64% for IMRT and respectively 11% and 18% for CRT. As a result, 6 weeks after treatment, the number of parotid flow complications was significantly lower after IMRT (55%) than after CRT (87%) (p = 0.002). The number of complications 6 months after treatment was 56% for IMRT and 81% for CRT (p = 0.04). CONCLUSIONS: IMRT significantly reduces the number of parotid flow complications for patients with oropharyngeal cancer.
Authors:
Pètra M Braam; Chris H J Terhaard; Judith M Roesink; Cornelis P J Raaijmakers
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Publication Detail:
Type:  Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-09-11
Journal Detail:
Title:  International journal of radiation oncology, biology, physics     Volume:  66     ISSN:  1879-355X     ISO Abbreviation:  Int. J. Radiat. Oncol. Biol. Phys.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-12-05     Completed Date:  2007-11-06     Revised Date:  2008-10-07    
Medline Journal Info:
Nlm Unique ID:  7603616     Medline TA:  Int J Radiat Oncol Biol Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  975-80     Citation Subset:  IM    
Affiliation:
Department of Radiotherapy, University Medical Center Utrecht, Utrecht, The Netherlands. P.M.Braam@umcutrecht.nl
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Female
Humans
Male
Middle Aged
Oropharyngeal Neoplasms / complications,  radiotherapy*
Radiation Injuries / etiology*,  prevention & control*
Radiotherapy, Conformal / adverse effects*
Risk Assessment
Risk Factors
Treatment Outcome
Xerostomia / etiology*,  prevention & control*

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