| Intensified therapy in acute lymphoblastic and acute undifferentiated leukemia in adults. | |
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MedLine Citation:
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PMID: 6375764 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One hundred seventy adult patients with acute lymphoblastic leukemia (ALL) or acute undifferentiated leukemia (AUL) were entered into a prospective multicenter therapy trial at 25 hospitals. The aim of the trial was to improve remission duration by using a modified form of an intensified induction regimen that was successful in childhood ALL, to define immunologic subtypes of ALL by use of cell-surface markers, and to extract other possible prognostic factors. The overall complete remission rate was 77.8%. The median overall survival time was 26 months, being 4 months for nonresponders and 32 months for responders. The median remission duration for the 126 patients with complete remission was 20 months. Prognostically favorable factors for remission duration were response to chemotherapy within 4 weeks, age less than 35 years, a low initial leukocyte count, and the immunologic subtypes c-ALL with early response to therapy and T-ALL, where 61% and 58%, respectively, are still in complete remission at 3 years. An adverse influence on remission duration was observed for the subtype null-ALL, with a median survival of 13 months, and for patients with a delayed response to induction therapy, independent of phenotype. |
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Authors:
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D Hoelzer; E Thiel; H Löffler; H Bodenstein; L Plaumann; T Büchner; D Urbanitz; P Koch; H Heimpel; R Engelhardt |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Blood Volume: 64 ISSN: 0006-4971 ISO Abbreviation: Blood Publication Date: 1984 Jul |
Date Detail:
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Created Date: 1984-07-30 Completed Date: 1984-07-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 38-47 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Age Factors Aged Antineoplastic Agents / adverse effects, therapeutic use B-Lymphocytes / immunology Clinical Trials as Topic Humans Leukemia / drug therapy*, mortality Leukemia, Lymphoid / drug therapy* Leukocyte Count Middle Aged Prospective Studies Receptors, Antigen, B-Cell / immunology Statistics as Topic T-Lymphocytes / immunology |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Receptors, Antigen, B-Cell |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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