Document Detail


Intensified large artery and microvascular response to cold adrenergic stimulation in African blacks.
MedLine Citation:
PMID:  19521343     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Arterial stiffening is more accelerated in blacks than in whites. Whether this is attributed to an enhanced vascular reactivity to environmental stress stimulation remains unknown. We therefore decided to test the hypothesis that cold pressor test (CPT) elicits a greater increase in arterial stiffness and an enhanced sympathetic skin vasoconstriction in African blacks than in whites normotensives.
METHODS: A total of 17 young normotensive African blacks and 17 normotensive whites were recruited. All underwent continuous assessment of blood pressure (BP), heart rate, and carotid-femoral pulse wave velocity (PWVc-f) at rest, during and after hand immersion in iced water (CPT). Concomitantly, skin microvascular blood flow was monitored by laser Doppler flowmetry on the opposite hand.
RESULTS: At baseline, African blacks exhibited higher values of PWVc-f than whites (7.2 +/- 0.3 vs. 6.5 +/- 0.2 m/s, respectively, P = 0.04). During CPT the increases in systolic BP and PWVc-f were greater in African blacks than in whites (systolic BP 17 +/- 2 mm Hg vs. 9 +/- 3 mm Hg, P < 0.001 and PWVc-f 0.62 +/- 0.1 m/s vs. 0.26 +/- 0.1 m/s, P = 0.03, respectively). However, there was no significant difference in the PWVc-f responses among the groups during CPT after adjustment for the increments in mean BP. Finally, CPT induced a more pronounced skin microvascular vasoconstriction in African blacks than in whites (-54.4 +/- 5 % vs. -31.3 +/- 6 %, P < 0.001).
CONCLUSIONS: CPT provokes a more pronounced increase in PWVc-f in normotensive African blacks than in whites, that appears to be due to a greater increase in mean BP. Additionally, African blacks present an intensified skin microvascular response to the CPT as compared to their whites counterparts.
Authors:
Dionysios Adamopoulos; William Ngatchou; Daniel Lemogoum; Christophe Janssen; Sofia Beloka; Oliver Lheureux; Patricia Kayembe; Jean-François Argacha; Jean-Paul Degaute; Philippe van de Borne
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-11
Journal Detail:
Title:  American journal of hypertension     Volume:  22     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-24     Completed Date:  2009-12-03     Revised Date:  2011-06-30    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  958-63     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium. adamopoulos1@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Africa / ethnology
African Continental Ancestry Group*
Blood Pressure / physiology*
Carotid Arteries / physiology
Cold Temperature*
Elasticity
European Continental Ancestry Group
Femoral Artery / physiology
Heart Rate / physiology
Humans
Laser-Doppler Flowmetry
Male
Pulse
Regional Blood Flow
Skin / blood supply
Vascular Resistance / drug effects,  physiology*
Vasoconstriction

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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