| Intensified large artery and microvascular response to cold adrenergic stimulation in African blacks. | |
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MedLine Citation:
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PMID: 19521343 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Arterial stiffening is more accelerated in blacks than in whites. Whether this is attributed to an enhanced vascular reactivity to environmental stress stimulation remains unknown. We therefore decided to test the hypothesis that cold pressor test (CPT) elicits a greater increase in arterial stiffness and an enhanced sympathetic skin vasoconstriction in African blacks than in whites normotensives. METHODS: A total of 17 young normotensive African blacks and 17 normotensive whites were recruited. All underwent continuous assessment of blood pressure (BP), heart rate, and carotid-femoral pulse wave velocity (PWVc-f) at rest, during and after hand immersion in iced water (CPT). Concomitantly, skin microvascular blood flow was monitored by laser Doppler flowmetry on the opposite hand. RESULTS: At baseline, African blacks exhibited higher values of PWVc-f than whites (7.2 +/- 0.3 vs. 6.5 +/- 0.2 m/s, respectively, P = 0.04). During CPT the increases in systolic BP and PWVc-f were greater in African blacks than in whites (systolic BP 17 +/- 2 mm Hg vs. 9 +/- 3 mm Hg, P < 0.001 and PWVc-f 0.62 +/- 0.1 m/s vs. 0.26 +/- 0.1 m/s, P = 0.03, respectively). However, there was no significant difference in the PWVc-f responses among the groups during CPT after adjustment for the increments in mean BP. Finally, CPT induced a more pronounced skin microvascular vasoconstriction in African blacks than in whites (-54.4 +/- 5 % vs. -31.3 +/- 6 %, P < 0.001). CONCLUSIONS: CPT provokes a more pronounced increase in PWVc-f in normotensive African blacks than in whites, that appears to be due to a greater increase in mean BP. Additionally, African blacks present an intensified skin microvascular response to the CPT as compared to their whites counterparts. |
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Authors:
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Dionysios Adamopoulos; William Ngatchou; Daniel Lemogoum; Christophe Janssen; Sofia Beloka; Oliver Lheureux; Patricia Kayembe; Jean-François Argacha; Jean-Paul Degaute; Philippe van de Borne |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-06-11 |
Journal Detail:
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Title: American journal of hypertension Volume: 22 ISSN: 1941-7225 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-24 Completed Date: 2009-12-03 Revised Date: 2011-06-30 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 958-63 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium. adamopoulos1@gmail.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Africa / ethnology African Continental Ancestry Group* Blood Pressure / physiology* Carotid Arteries / physiology Cold Temperature* Elasticity European Continental Ancestry Group Femoral Artery / physiology Heart Rate / physiology Humans Laser-Doppler Flowmetry Male Pulse Regional Blood Flow Skin / blood supply Vascular Resistance / drug effects, physiology* Vasoconstriction |
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