Document Detail


Intensified chemotherapy for childhood lymphoblastic leukemia: modifications and results of induction treatment in St. Jude Study XI.
MedLine Citation:
PMID:  3214044     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The value of intensified chemotherapy for improving event-free survival rates in childhood lymphoblastic leukemia (ALL) is now widely accepted among leukemia therapists. Still to be determined are (1) the optimal method of intensification, (2) the subset or subsets of patients for whom such treatment may be excessive, and (3) whether or not cure rates in ALL can be further improved by alternative approaches to intensification. St. Jude Total Therapy Study XI, based on predictions of the Goldie-Coldmand model of drug resistance, addresses some of these questions by use of rotational "non-cross-resistant" drug pairs throughout the course of therapy. A new method of risk classification has been developed to refine distinctions among prognostic subgroups, especially to identify patients with biologically unfavorable ALL. Unacceptable toxicity noted in the first 134 children enrolled in this study led to two protocol modifications. One hundred thirty-two patients have been treated subsequently without undue toxicity. The treatment is now being delivered safely. Our early experience with this regimen demonstrates some of the hazards of intensive multidrug combination treatment, but gains in leukemia control appear to justify this approach.
Authors:
G K Rivera; D K Kalwinsky; J Mirro; C H Pui; M Abromowitch; J Ochs; W Furman; V Santana; A T Look; L W Dow
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anales españoles de pediatría     Volume:  29 Suppl 34     ISSN:  0302-4342     ISO Abbreviation:  An. Esp. Pediatr.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1989-02-21     Completed Date:  1989-02-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0420463     Medline TA:  An Esp Pediatr     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  83-8     Citation Subset:  IM    
Affiliation:
St. Jude Children's Research Hospital, Department of Hematology-Oncology, Memphis, Tennessee, 38015.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / adverse effects,  therapeutic use*
Child
Child, Preschool
Clinical Protocols
Humans
Infant
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
Remission Induction
Risk Factors
Chemical
Reg. No./Substance:
0/Antineoplastic Agents

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