Document Detail

Intensified effect of adiposity on blood pressure in overweight and obese children.
MedLine Citation:
PMID:  21968752     Owner:  NLM     Status:  MEDLINE    
In children, blood pressure (BP) and risk for hypertension are proportional to degree of adiposity. Whether the relationship to BP is similar over the full range of adiposity is less clear. Subjects from a cohort study (n=1111; 50% male and 42% black) contributed 9102 semiannual BP and height/weight assessments. The mean enrollment age was 10.2 years, and mean follow-up was 4.5 years. Adiposity was expressed as body mass index percentile, which accounted for effects of age and sex. The following observations were made. The effect of relative adiposity on BP was minimal until the body mass index percentile reached 85, beginning of the overweight category, at which point the effect of adiposity on BP increased by 4-fold. Similarly intensified adiposity effects on BP were observed in children aged ≤10, 11 to 14 years, and ≥15 years. Serum levels of the adipose tissue-derived hormone, leptin, together with heart rate, showed an almost identically patterned relation to BP to that of body mass index percentile and BP, thus implicating a possible mediating role for leptin. In conclusion, there is a marked intensification of the influence of adiposity on BP when children reach the categories of overweight and obese. Among the possible pathways, leptin may be a potentially important mediator acting through the sympathetic nervous system (reflected in heart rate). The findings have relevance to interventions designed to prevent or treat adiposity-related increases in BP and to the analytic approaches used in epidemiological studies.
Wanzhu Tu; George J Eckert; Linda A DiMeglio; Zhangsheng Yu; Jeesun Jung; J Howard Pratt
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2011-10-03
Journal Detail:
Title:  Hypertension     Volume:  58     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-21     Completed Date:  2011-12-15     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  818-24     Citation Subset:  IM    
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MeSH Terms
Age Factors
Blood Pressure Determination
Body Mass Index*
Child, Preschool
Cross-Sectional Studies
Hypertension / diagnosis,  epidemiology*
Leptin / metabolism
Obesity / epidemiology
Overweight / epidemiology*
Risk Assessment
United States
Grant Support
R01 HL095086/HL/NHLBI NIH HHS; R01 HL095086-03/HL/NHLBI NIH HHS; R01 HL095086-04/HL/NHLBI NIH HHS; R01-HL095086/HL/NHLBI NIH HHS
Reg. No./Substance:
Comment In:
Hypertension. 2011 Nov;58(5):754-5   [PMID:  21968756 ]

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