| Intense pulsed light in photoaging: a clinical, histopathological and immunohistochemical evaluation. | |
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MedLine Citation:
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PMID: 22281900 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Intense pulsed light has been used in the treatment of photoaging without a full understanding of its mechanism of action. OBJECTIVE: To study the effect of intense pulsed light on photoaging and on the skin immune response by means of a clinical and histopathological study, evaluating Langerhans cells (CD1), expression of intercellular adhesion molecule, of CD4 and CD8 lymphocytes and quantification of collagen and elastic fibers. METHODS: In 2006 a total of 26 patients, aged 40 to 65 years, with phototypes II to III (Fitzpatrick scale), were treated for photoaging using intense pulsed light in five sessions with a monthly interval. All the patients were subjected to histological and immunohistochemical evaluation 6 months after treatment. RESULTS: At the end of the treatment clinical improvement was observed in 76.92% of cases. This improvement was associated to a significant increase of collagen (51.33%) and elastic (44.13%) fibers. Intense pulsed light treatment led to a reduction of CD4 lymphocytes and did not alter the amount of CD8 lymphocytes. It also led to a significant increase of small, nonectatic blood vessels, positive intercellular adhesion molecule. CONCLUSION: Facial treatment with intense pulsed light promoted major clinical improvement that was confirmed by histological examination of the skin. This technique is a good treatment option for skin photoaging because it is non-ablative, safe and effective. |
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Authors:
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Régia Celli Ribeiro Patriota; Consuelo Junqueira Rodrigues; Luiz Carlos Cucé |
Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Anais brasileiros de dermatologia Volume: 86 ISSN: 1806-4841 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-1-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0067662 Medline TA: An Bras Dermatol Country: - |
Other Details:
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Languages: ENG; POR Pagination: 1129-1133 Citation Subset: - |
Affiliation:
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Departamento de Dermatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil. |
Vernacular Title:
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Luz intensa pulsada no fotoenvelhecimento: avaliação clínica, histopatológica e imuno-histoquímica. |
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