Document Detail

Intense oxidative DNA damage promoted by L-dopa and its metabolites. Implications for neurodegenerative disease.
MedLine Citation:
PMID:  7957867     Owner:  NLM     Status:  MEDLINE    
Oxidative DNA damage can cause mutation and cell death. We show that L-DOPA, dopamine and 3-O-methyl-DOPA cause extensive oxidative DNA damage in the presence of H2O2 and traces of copper ions. 8-Hydroxyguanine is the major product. Iron ions were much less effective and manganese ions did not catalyse DNA damage. We propose that copper ion release, in the presence of L-DOPA and its metabolites, may be an important mechanism of neurotoxicity, e.g. in Parkinson's disease and amyotrophic lateral sclerosis.
J P Spencer; A Jenner; O I Aruoma; P J Evans; H Kaur; D T Dexter; P Jenner; A J Lees; D C Marsden; B Halliwell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  353     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1994-11-29     Completed Date:  1994-11-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  246-50     Citation Subset:  IM    
Neurodegenerative Disease Research Centre, King's College, London, UK.
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MeSH Terms
Brain Chemistry
Copper / analysis,  toxicity*
DNA / drug effects*
DNA Damage*
Dopamine / pharmacology
Hydrogen Peroxide
Iron / analysis,  toxicity
Levodopa / pharmacology*
Parkinson Disease / metabolism*
Tyrosine / analogs & derivatives,  pharmacology
Reg. No./Substance:
0/Levodopa; 55520-40-6/Tyrosine; 7439-89-6/Iron; 7440-50-8/Copper; 7636-26-2/3-methoxytyrosine; 7722-84-1/Hydrogen Peroxide; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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