Document Detail


Intense oxidative DNA damage promoted by L-dopa and its metabolites. Implications for neurodegenerative disease.
MedLine Citation:
PMID:  7957867     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxidative DNA damage can cause mutation and cell death. We show that L-DOPA, dopamine and 3-O-methyl-DOPA cause extensive oxidative DNA damage in the presence of H2O2 and traces of copper ions. 8-Hydroxyguanine is the major product. Iron ions were much less effective and manganese ions did not catalyse DNA damage. We propose that copper ion release, in the presence of L-DOPA and its metabolites, may be an important mechanism of neurotoxicity, e.g. in Parkinson's disease and amyotrophic lateral sclerosis.
Authors:
J P Spencer; A Jenner; O I Aruoma; P J Evans; H Kaur; D T Dexter; P Jenner; A J Lees; D C Marsden; B Halliwell
Related Documents :
16846977 - Cationic peptides containing tyrosine protect against radiation-induced oxidative dna d...
14718177 - Oxidative damage to nuclear dna in hyperthyroid rat liver: inability of vitamin c to pr...
25440997 - Xerc-mediated dna inversion at the inverted repeats of the uu172-phase-variable element...
12726997 - Dna damage measured by liquid chromatography-mass spectrometry in mouse fibroblast cell...
17338557 - Probing the permeability of polyelectrolyte multilayer capsules via a molecular beacon ...
18304797 - Enzymatic amplification detection of dna based on "molecular beacon" biosensors.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  353     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1994-11-29     Completed Date:  1994-11-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  246-50     Citation Subset:  IM    
Affiliation:
Neurodegenerative Disease Research Centre, King's College, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Brain Chemistry
Catalysis
Copper / analysis,  toxicity*
DNA / drug effects*
DNA Damage*
Dopamine / pharmacology
Humans
Hydrogen Peroxide
Iron / analysis,  toxicity
Levodopa / pharmacology*
Oxidation-Reduction
Parkinson Disease / metabolism*
Tyrosine / analogs & derivatives,  pharmacology
Chemical
Reg. No./Substance:
0/Levodopa; 55520-40-6/Tyrosine; 7439-89-6/Iron; 7440-50-8/Copper; 7636-26-2/3-methoxytyrosine; 7722-84-1/Hydrogen Peroxide; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Selective inactivity of TGF-beta/decorin complexes.
Next Document:  Changes in activation gating of IsK potassium currents brought about by mutations in the transmembra...