| Intense exercise induces mitochondrial dysfunction in mice brain. | |
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MedLine Citation:
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PMID: 17619145 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There are conflicts between the effects of free radical over-production induced by exercise on neurotrophins and brain oxidative metabolism. The objective of this study was to investigate the effects of intense physical training on brain-derived neurotrophic factor (BDNF) levels, COX activity, and lipoperoxidation levels in mice brain cortex. Twenty-seven adult male CF1 mice were assigned to three groups: control untrained, intermittent treadmill exercise (3 x 15 min/day) and continuous treadmill exercise (45 min/day). Training significantly (P < 0.05) increased citrate synthase activity when compared to untrained control. Blood lactate levels classified the exercise as high intensity. The intermittent training significantly (P < 0.05) reduced in 6.5% the brain cortex COX activity when compared to the control group. BDNF levels significantly (P < 0.05) decreased in both exercise groups. Besides, continuous and intermittent exercise groups significantly (P < 0.05) increased thiobarbituric acid reactive species levels in the brain cortex. In summary, intense exercise promoted brain mitochondrial dysfunction due to decreased BDNF levels in the frontal cortex of mice. |
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Authors:
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Aderbal S Aguiar; Talita Tuon; Cléber A Pinho; Luciano A Silva; Ana C Andreazza; Flávio Kapczinski; João Quevedo; Emílio L Streck; Ricardo A Pinho |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-07-06 |
Journal Detail:
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Title: Neurochemical research Volume: 33 ISSN: 0364-3190 ISO Abbreviation: Neurochem. Res. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2007-12-10 Completed Date: 2008-04-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: United States |
Other Details:
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Languages: eng Pagination: 51-8 Citation Subset: IM |
Affiliation:
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Laboratory of Exercise Physiology and Biochemistry, Post-graduation Program in Health Sciences, Universidade do Extremo Sul Catarinense, Criciúma, SC 88806-000, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Animals Brain / enzymology, physiopathology* Brain-Derived Neurotrophic Factor / metabolism Electron Transport Complex IV / metabolism Lipid Peroxidation Male Mice Mitochondria / physiology* Physical Conditioning, Animal* |
| Chemical | |
Reg. No./Substance:
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0/Brain-Derived Neurotrophic Factor; EC 1.9.3.1/Electron Transport Complex IV |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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