Document Detail

Intelligence of very preterm or very low birthweight infants in young adulthood.
MedLine Citation:
PMID:  18805824     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the effect of intrauterine and neonatal growth, prematurity and personal and environmental risk factors on intelligence in adulthood in survivors of the early neonatal intensive care era. METHODS: A large geographically based cohort comprised 94% of all babies born alive in the Netherlands in 1983 with a gestational age below 32 weeks and/or a birth weight >1500 g (POPS study). Intelligence was assessed in 596 participants at 19 years of age. Intrauterine and neonatal growth were assessed at birth and 3 months of corrected age. Environmental and personal risk factors were maternal age, education of the parent, sex and origin. RESULTS: The mean (SD) IQ of the cohort was 97.8 (15.6). In multiple regression analysis, participants with highly educated parents had a 14.2-point higher IQ than those with less well-educated parents. A 1 SD increase in birth weight was associated with a 2.6-point higher IQ, and a 1-week increase in gestational age was associated with a 1.3-point higher IQ. Participants born to young mothers (<25 years) had a 2.7-point lower IQ, and men had a 2.1-point higher IQ than women. The effect on intelligence after early (symmetric) intrauterine growth retardation was more pronounced than after later (asymmetric) intrauterine or neonatal growth retardation. These differences in mean IQ remained when participants with overt handicaps were excluded. CONCLUSIONS: Prematurity as well as the timing of growth retardation are important for later intelligence. Parental education, however, best predicted later intelligence in very preterm or very low birthweight infants.
N Weisglas-Kuperus; E T M Hille; H J Duivenvoorden; M J J Finken; J M Wit; S van Buuren; J B van Goudoever; S P Verloove-Vanhorick;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-09-19
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  94     ISSN:  1468-2052     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-22     Completed Date:  2009-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  England    
Other Details:
Languages:  eng     Pagination:  F196-200     Citation Subset:  AIM; IM    
Division of Neonatology, Department of Pediatrics, Erasmus MC-Sophia Children's Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands.
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MeSH Terms
Child Development*
Cohort Studies
Educational Status
Fetal Growth Retardation / epidemiology
Gestational Age*
Infant, Newborn
Infant, Very Low Birth Weight
Maternal Age
Netherlands / epidemiology
Risk Factors
Young Adult
E T M Hille / ; C H de Groot / ; H Kloosterboer-Boerrigter / ; A L den Ouden / ; A Rijpstra / ; S P Verloove-Vanhorick / ; J A Vogelaar / ; J H Kok / ; A Ilsen / ; M van der Lans / ; W J C Boelen-van der Loo / ; T Lundqvist / ; H S A Heymans / ; E J Duiverman / ; W B Geven / ; M L Duiverman / ; L I Geven / ; E J L E Vrijlandt / ; A L M Mulder / ; A Gerver / ; L A A Kollée / ; L Reijmers / ; R Sonnemans / ; J M Wit / ; F W Dekker / ; M J J Finken / ; N Weisglas-Kuperus / ; M G Keijzer-Veen / ; A van der Heijden / ; J B van Goudoever / ; M M van Weissenbruch / ; A Cranendonk / ; H A Delemarre-van de Waal / ; L de Groot / ; J F Samsom / ; L S de Vries / ; K J Rademaker / ; E Moerman / ; M Voogsgeerd / ; M J K de Kleine / ; P Andriessen / ; C C M Dielissen-van Helvoirt / ; I Mohamed / ; H L M van Straaten / ; W Baerts / ; G W Veneklaas Slots-Kloosterboer / ; E M J Tuller-Pikkemaat / ; M H Ens-Dokkum / ; G J van Steenbrugge /

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