Document Detail

Intelligence in childhood and chronic widespread pain in middle age: the National Child Development Survey.
MedLine Citation:
PMID:  23137899     Owner:  NLM     Status:  MEDLINE    
Psychological factors are thought to play a part in the aetiology of chronic widespread pain. We investigated the relationship between intelligence in childhood and risk of chronic widespread pain in adulthood in 6902 men and women from the National Child Development Survey (1958 British Birth Cohort). Participants took a test of general cognitive ability at age 11 years; and chronic widespread pain, defined according to the American College of Rheumatology criteria, was assessed at age 45 years. Risk ratios (RRs) and 95% confidence intervals (CIs) were estimated using log-binomial regression, adjusting for sex and potential confounding or mediating factors. Risk of chronic widespread pain, defined according to the American College of Rheumatology criteria, rose in a stepwise fashion as intelligence fell (P for linear trend <0.0001). In sex-adjusted analyses, for an SD lower intelligence quotient, the RR of chronic widespread pain was 1.26 (95% CI 1.17-1.35). In multivariate backwards stepwise regression, lower childhood intelligence remained as an independent predictor of chronic widespread pain (RR 1.10; 95% CI 1.01-1.19), along with social class, educational attainment, body mass index, smoking status, and psychological distress. Part of the effect of lower childhood intelligence on risk of chronic widespread pain in midlife was significantly mediated through greater body mass index and more disadvantaged socioeconomic position. Men and women with higher intelligence in childhood are less likely as adults to report chronic widespread pain.
Catharine R Gale; Ian J Deary; Cyrus Cooper; G David Batty
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pain     Volume:  153     ISSN:  1872-6623     ISO Abbreviation:  Pain     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-09     Completed Date:  2013-04-30     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  7508686     Medline TA:  Pain     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2339-44     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
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MeSH Terms
Child Development*
Child, Preschool
Chronic Pain / diagnosis*,  epidemiology*,  psychology
Cognitive Reserve*
Data Collection
Great Britain / epidemiology
Intelligence Tests / statistics & numerical data*
Longitudinal Studies
Middle Aged
Risk Factors
Sex Distribution
Socioeconomic Factors
Grant Support
G0700704//Medical Research Council; G1001799//Medical Research Council; MC_UP_A620_1014//Medical Research Council; MC_UP_A620_1015//Medical Research Council; MC_UU_12011/2//Medical Research Council; //Biotechnology and Biological Sciences Research Council; //Medical Research Council; //Wellcome Trust
Comment In:
Pain. 2013 Oct;154(10):2238   [PMID:  23891682 ]
Pain. 2012 Dec;153(12):2305-6   [PMID:  23009898 ]
Pain. 2013 Oct;154(10):2237   [PMID:  23891681 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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