Document Detail


Intelligence and event-related potentials for young female human volunteer apolipoprotein E epsilon4 and non-epsilon4 carriers.
MedLine Citation:
PMID:  11072144     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The apolipoprotein E (APOE) epsilon4 allele is associated with late-onset Alzheimer's disease and cognitive function in aging normal populations. To study the effect of the presence of the epsilon4 allele on cognitive function, we compared intelligence-test scores and component values for event-related potentials for epsilon4 and non-epsilon4 carriers in a group of 134 young females. The results demonstrate modest increases in performance intelligence quotient (IQ) and N100 amplitude for epsilon4 carriers (P=0.038 and 0.068, respectively). Our findings suggest that cognitive impairment, associated with the presence of the epsilon4 allele, is age-dependent and thus not probable for young women. The higher performance IQ scores demonstrated for epsilon4 carriers require further exploration.
Authors:
Y W Yu; C H Lin; S P Chen; C J Hong; S J Tsai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  294     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-12-27     Completed Date:  2000-12-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  179-81     Citation Subset:  IM    
Affiliation:
Yu's Psychiatric Clinic, Kaohsiung, Taiwan, ROC.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alzheimer Disease / genetics
Apolipoprotein E4
Apolipoproteins E / genetics*
Evoked Potentials, Auditory / genetics*
Female
Heterozygote
Humans
Intelligence / genetics*
Intelligence Tests*
Chemical
Reg. No./Substance:
0/Apolipoprotein E4; 0/Apolipoproteins E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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