Document Detail

Intellectual outcomes of patients with congenital hypothyroidism not detected by neonatal screening.
MedLine Citation:
PMID:  10463002     Owner:  NLM     Status:  MEDLINE    
Mental retardation is a major sequela of delayed treatment of congenital hypothyroidism. In this study, we investigated the intellectual outcomes of patients with congenital hypothyroidism diagnosed before a nationwide screening project started. Eighty-two patients had intelligence tests done while in the euthyroid state. Their mean intelligence quotient (IQ) was 78 +/- 21 (+/- SD) (n = 79). The mean verbal IQ was significantly higher than the mean full-scale IQ. The mean IQs of both ectopic thyroid (84 +/- 21, n = 28) and dyshormonogenic patients (85 +/- 14, n = 18) were significantly higher than that of patients with athyrosis (64 +/- 18, n = 19) (p < 0.05). Patients who were treated before 3 months of age had significantly higher mean IQs (90 +/- 16, n = 16) than those treated after 3 months (75 +/- 21, n = 63) (p < 0.01). Our results confirm that both patients with ectopic thyroids and those with dyshormonogenesis have better intellectual outcomes than athyrotic patients do, and that early treatment improves the intellectual outcome of patients with congenital hypothyroidism.
P H Hsiao; Y N Chiu; W Y Tsai; S C Su; J S Lee; W T Soong
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Formosan Medical Association = Taiwan yi zhi     Volume:  98     ISSN:  0929-6646     ISO Abbreviation:  J. Formos. Med. Assoc.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-09-14     Completed Date:  1999-09-14     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9214933     Medline TA:  J Formos Med Assoc     Country:  CHINA (REPUBLIC: 1949- )    
Other Details:
Languages:  eng     Pagination:  512-5     Citation Subset:  IM    
Department of Pediatrics, National Taiwan University Hospital, Taipei.
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MeSH Terms
Age Factors
Analysis of Variance
Child, Preschool
Congenital Hypothyroidism*
Follow-Up Studies
Hypothyroidism / complications,  therapy
Infant, Newborn
Mental Retardation / epidemiology*,  etiology,  prevention & control
Neonatal Screening

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