| Intellectual functioning in pediatric patients with epilepsy: a comparison of medically controlled, medically uncontrolled and surgically controlled children. | |
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MedLine Citation:
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PMID: 20938589 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the intellectual coefficient (IQ) of three groups of children with epilepsy: 1) medically controlled, 2) medically uncontrolled and 3) surgically controlled. METHODS: From December 2007 until July 2008, 98 pediatric patients were selected, with an age range between 6 and 12 years. Neuropsychological assessment included the Wechsler Intelligence Scale for Children-third edition (WISC-III). Results are related to epileptic syndrome, etiology of epilepsy, drug therapy, age at epilepsy onset and epilepsy duration. RESULTS: WISC scores were significantly better in the medically controlled group when compared to the medically uncontrolled group. The medically controlled group performed significantly better in the majority of the WISC subtests when compared to the medically uncontrolled group: vocabulary, arithmetic, comprehension, digit span, picture completion, picture arrangement, and block design. A significantly higher number of idiopathic epilepsy and monotherapy cases was observed in the medically controlled group when compared to the medically uncontrolled group. Surgically controlled children had no significant differences in IQ performance when compared to medically controlled children. CONCLUSIONS: Children with good seizure control have higher general, verbal and performed intelligence when compared to children with refractory epilepsy. These results may be influenced by clinical factors such as use of monotherapy, drug type and epileptic syndrome and etiology. Epilepsy surgery can have a positive impact on cognitive performance of children who were free of seizures after surgery. |
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Authors:
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Cecília Souza-Oliveira; Sara Escosi-Rosset; Sandra S Funayama; Vera C Terra; Hélio R Machado; Américo C Sakamoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Jornal de pediatria Volume: 86 ISSN: 1678-4782 ISO Abbreviation: J Pediatr (Rio J) Publication Date: 2010 Sep-Oct |
Date Detail:
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Created Date: 2010-10-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985188R Medline TA: J Pediatr (Rio J) Country: Brazil |
Other Details:
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Languages: eng; por Pagination: 377-83 Citation Subset: IM |
Affiliation:
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Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil. cecilia@rnp.fmrp.usp.br |
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Comment In:
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J Pediatr (Rio J). 2010 Sep-Oct;86(5):349-50
[PMID:
20938585
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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