Document Detail

Intellectual ability and executive function in pediatric moyamoya vasculopathy.
MedLine Citation:
PMID:  22117564     Owner:  NLM     Status:  Publisher    
Aim  Moyamoya vasculopathy is characterized by progressive stenosis of the major arteries of the Circle of Willis, resulting in compromised cerebral blood flow and increased risk of stroke. The objectives of the current study were to examine intellectual and executive functioning of children with moyamoya and to evaluate the impact of moyamoya type, stroke (clinical or silent), vasculopathy laterality, and disease duration on neurocognitive abilities. Method  Thirty pediatric participants (mean age 10y 10mo, SD 4y; 18 females, 12 males) completed age-appropriate Wechsler Intelligence Scales before any therapeutic revascularization procedures. Reports of executive function were obtained from parents and teachers using the Behavior Rating Index of Executive Function. Results  Children with moyamoya scored significantly lower than the test standardization samples on all indices of intelligence and ratings of executive functioning (p<0.001). Patients did not differ by type of moyamoya or history of stroke. Patients with bilateral disease and stroke scored significantly lower than those with unilateral disease on measures of overall intellectual function (p=0.035) and verbal comprehension (p=0.04). Deficits in metacognitive executive functions were also more pronounced in bilateral patients according to teacher ratings. Interpretation  Children with moyamoya are at risk for intellectual and executive problems, exacerbated by bilateral disease and clinical stroke history.
Tricia S Williams; Robyn Westmacott; Nomazulu Dlamini; Leeor Granite; Peter Dirks; Rand Askalan; Daune Macgregor; Mahendranath Moharir; Gabrielle Deveber
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-24
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  -     ISSN:  1469-8749     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© The Authors. Developmental Medicine & Child Neurology © 2011 Mac Keith Press.
 Department of Psychology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada  Children's Stroke Program, The Hospital for Sick Children, Division of Neurology, Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada  Evelina Children's Hospital, St Thomas Hospital, London, UK  Department of Neurosurgery, The Hospital for Sick Children, Division of Neurology, Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
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