Document Detail

Integrity of the inferior longitudinal fasciculus and impaired object recognition in children: a diffusion tensor imaging study.
MedLine Citation:
PMID:  22171928     Owner:  NLM     Status:  In-Data-Review    
Aim  In this study, we explored the integrity of the inferior longitudinal fasciculus (ILF) by means of diffusion tensor imaging tractography in children with visual perceptual impairment, and more specifically, object recognition deficits, compared with typically developing children. Methods  Eleven individuals (nine males, two females; mean age 7y 8mo; range 3y 5mo-13y) were assessed with the L94 visual perceptual battery after assessment of performance age. In all participants, an ophthalmological evaluation was carried out. Diffusion tensor imaging tractography of the ILF was performed. The mean fractional anisotropy was determined for every child and compared with data for 11 age- and sex-matched typically developing children. Results  The mean fractional anisotropy value in the left ILF was consistently lower in the study participants than in the comparison group. The five children with L94 impairment showed a significantly lower ILF fractional anisotropy on the left as well as on the right side. Furthermore, the decrease in ILF fractional anisotropy was correlated with the number of impaired subtests. Interpretation  The results suggest an association between ILF integrity loss and object recognition deficits. Moreover, the severity of clinical impairment is reflected in the degree of ILF integrity loss. Therefore, the ILF plays a potential role in object recognition.
Els Ortibus; Judith Verhoeven; Stefan Sunaert; Ingele Casteels; Paul DE Cock; Lieven Lagae
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  54     ISSN:  1469-8749     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  38-43     Citation Subset:  IM    
Copyright Information:
© The Authors. Developmental Medicine & Child Neurology © 2011 Mac Keith Press.
Paediatric Neurology Department, University Hospitals of the Catholic University of Leuven, Leuven  Medical Imaging Centre, University Hospitals of the Catholic University of Leuven, Leuven  Paediatric Ophthalmology Department, University Hospitals of the Catholic University of Leuven, Leuven, Belgium.
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