Document Detail


Integrins in Periodontal Disease.
MedLine Citation:
PMID:  24662197     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Cell surface integrin receptors mediate cell adhesion, migration and cellular signaling in all nucleated cells. They are activated by binding to extracellular ligands or by intracellular proteins, such as kindlins that engage with their cytoplasmic tails. Cells in the periodontal tissues express several integrins with overlapping ligand-binding capabilities. A distinct phenotype in the periodontium has only been described for knockouts or mutations of three integrin subunits, α11, β6 and β2. Integrin α11β1 appears to have some regulatory function in the periodontal ligament of continuously erupting incisors in mice. Integrin αvβ6 is expressed in the junctional epithelium (JE) of the gingiva. Animals deficient in this receptor develop classical signs of periodontal disease, including inflammation, apical migration of the JE and bone loss, suggesting that it plays a role in the regulation of periodontal inflmmation, likely through activation of transforming growth factor-β1. Lack of integrin activation in the JE is also associated with periodontitis. Patients with kindlin-1 mutations have severe early-onset periodontal disease. Finally, patients with mutations in the leukocyte-specific β2 integrin subunit have severe periodontal problems due to lack of transiting neutrophils in the periodontal tissues.
Authors:
Hannu Larjava; Leeni Koivisto; Jyrki Heino; Lari Häkkinen
Related Documents :
25101167 - Vegfr-1 blockade disrupts peri-implantation decidual angiogenesis and macrophage recrui...
17541067 - Membrane-type 1 matrix metalloproteinase stimulates cell migration through epidermal gr...
17096527 - Recombinant protein-co-peg networks as cell-adhesive and proteolytically degradable hyd...
24707837 - Chondrogenic differentiation of adipose-derived stromal cells in combinatorial hydrogel...
9858477 - Role of collagenase in mediating in vitro alveolar epithelial wound repair.
1716917 - Regression of atherosclerosis. a role for calcium antagonists.
Publication Detail:
Type:  REVIEW     Date:  2014-3-21
Journal Detail:
Title:  Experimental cell research     Volume:  -     ISSN:  1090-2422     ISO Abbreviation:  Exp. Cell Res.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373226     Medline TA:  Exp Cell Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Inc.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Angiotensin II type 1 receptor blockade suppresses light-induced neural damage in the mouse retina.
Next Document:  Lipid rafts are required for signal transduction by AGTR1 in neonatal glomerular mesangial cells.