Document Detail

Integrins and cadherins join forces to form adhesive networks.
MedLine Citation:
PMID:  21444749     Owner:  NLM     Status:  MEDLINE    
Cell-cell and cell-extracellular-matrix (cell-ECM) adhesions have much in common, including shared cytoskeletal linkages, signaling molecules and adaptor proteins that serve to regulate multiple cellular functions. The term 'adhesive crosstalk' is widely used to indicate the presumed functional communication between distinct adhesive specializations in the cell. However, this distinction is largely a simplification on the basis of the non-overlapping subcellular distribution of molecules that are involved in adhesion and adhesion-dependent signaling at points of cell-cell and cell-substrate contact. The purpose of this Commentary is to highlight data that demonstrate the coordination and interdependence of cadherin and integrin adhesions. We describe the convergence of adhesive inputs on cell signaling pathways and cytoskeletal assemblies involved in regulating cell polarity, migration, proliferation and survival, differentiation and morphogenesis. Cell-cell and cell-ECM adhesions represent highly integrated networks of protein interactions that are crucial for tissue homeostasis and the responses of individual cells to their adhesive environments. We argue that the machinery of adhesion in multicellular tissues comprises an interdependent network of cell-cell and cell-ECM interactions and signaling responses, and not merely crosstalk between spatially and functionally distinct adhesive specializations within cells.
Gregory F Weber; Maureen A Bjerke; Douglas W DeSimone
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Journal of cell science     Volume:  124     ISSN:  1477-9137     ISO Abbreviation:  J. Cell. Sci.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-29     Completed Date:  2011-09-02     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0052457     Medline TA:  J Cell Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  1183-93     Citation Subset:  IM    
Department of Cell Biology, School of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA.
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MeSH Terms
Cadherins / genetics,  metabolism*
Cell-Matrix Junctions / genetics,  metabolism*
Cytoskeleton / metabolism
Extracellular Matrix / metabolism
Integrins / genetics,  metabolism*
Signal Transduction
Grant Support
Reg. No./Substance:
0/Cadherins; 0/Integrins
Erratum In:
J Cell Sci. 2011 May 1;124(Pt 9):1601

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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