| Integrin signalling and function in immune cells. | |
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MedLine Citation:
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PMID: 22211918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Integrins not only mediate cell-cell and cell-extracellular matrix adhesion, but also affect the multitude of signal transduction cascades in control of cell survival, proliferation, differentiation and organ development. Mutations in integrins or the major effectors of integrin signalling pathways cause defective organ development, immunodeficiency, cancer or autoimmune disease. Understanding of the signalling events that drive integrin activation and signalling is therefore crucial to uncover the molecular mechanisms of these diseases. This review discusses the key signalling complexes regulating integrin activation and function in both 'inside-out' and 'outside-in' pathways in T lymphocytes, including kinases, SLP-76, VAV1, ADAP, SKAP-55, RapL, RIAM, Rap1, Talin and Kindlin. |
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Authors:
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Yanbo Zhang; Hongyan Wang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Immunology Volume: 135 ISSN: 1365-2567 ISO Abbreviation: Immunology Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-03-05 Completed Date: 2012-04-24 Revised Date: 2013-04-01 |
Medline Journal Info:
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Nlm Unique ID: 0374672 Medline TA: Immunology Country: England |
Other Details:
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Languages: eng Pagination: 268-75 Citation Subset: IM |
Copyright Information:
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© 2012 Shanghai Institute of Biochemistry and Cell Biology, SIBS, CAS. Immunology © 2012 Blackwell Publishing Ltd. |
Affiliation:
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The State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptor Proteins, Signal Transducing
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metabolism* Cell Adhesion Cell Communication Humans Immune System Diseases / etiology*, immunology Integrins / immunology, metabolism* Signal Transduction* T-Lymphocytes / cytology, immunology*, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Adaptor Proteins, Signal Transducing; 0/Integrins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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