Document Detail


Integrin expression on monocytes and lymphocytes in unstable angina short term effects of atorvastatin.
MedLine Citation:
PMID:  18333374     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inflammatory reactions in coronary plaques play an important role in the pathogenesis of acute atherothrombotic events. The most powerful class of lipid-lowering drugs available-statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors)--have additional actions, unrelated to cholesterol reduction, including anti-inflammatory and immunomodulatory properties. This study sought to determine if atorvastatin affects monocyte and lymphocyte activation in patients with unstable angina and mild primary hypercholesterolemia. Following a 4-weeks hypolipemiant-free baseline period, 22 patients-12 with unstable angina (UA) and 10 patients with stable coronary heart disease (SCHD) - were treated with Atorvastatin 20 mg/day. Lipopolysaccharide (LPS)-receptor (CD14) and HLA-DR expression on monocytes and beta-integrins (CD11b, 11c, 49d) on monocytes and lymphocytes were measured by flow cytometry before and after treatment with atorvastatin for 8 weeks. Monocyte CD11b, 11c and CD14 expression and T lymphocytes CD11b expression were significantly (p < 0.001) higher in UA patients before treatment when compared with that in SCHD patients. In patients with UA, they decreased markedly with atorvastatin treatment. The reduction in expression of adhesion molecule on monocytes and lymphocytes and the concentrations of CRP and sICAM-1 may crucially contribute to the clinical benefit of atorvastatin in coronary artery disease, independent of cholesterol lowering effects.
Authors:
Minodora Dobreanu; D Dobreanu; Andrea Fodor; Anca Bacarea
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Romanian journal of internal medicine = Revue roumaine de médecine interne     Volume:  45     ISSN:  1220-4749     ISO Abbreviation:  Rom J Intern Med     Publication Date:  2007  
Date Detail:
Created Date:  2008-03-12     Completed Date:  2008-04-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9304507     Medline TA:  Rom J Intern Med     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  193-9     Citation Subset:  IM    
Affiliation:
Department of Clinical Biochemistry-Immunology, University of Medicine and Pharmacy, Târgu Mureş, Romania. dobreanu@orizont.net
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MeSH Terms
Descriptor/Qualifier:
Adult
Angina, Unstable / complications*
Anticholesteremic Agents / pharmacology*
Case-Control Studies
Cohort Studies
Coronary Artery Disease / complications
Female
Flow Cytometry
Heptanoic Acids / pharmacology*
Humans
Hypercholesterolemia / complications*,  drug therapy*
Integrin alpha Chains / drug effects*,  metabolism
Lymphocyte Activation / drug effects
Male
Middle Aged
Monocytes / drug effects
Pyrroles / pharmacology*
T-Lymphocytes / drug effects
Chemical
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Heptanoic Acids; 0/Integrin alpha Chains; 0/Pyrroles; 110862-48-1/atorvastatin

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