| Integrin α6β4 in colorectal cancer. | |
| | |
MedLine Citation:
|
PMID: 21607137 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
|
The ability of cells to interact with extracellular matrix macromolecules is at the forefront of the regulation of cell phenotype and organization. Indeed most if not all cells bear specific cell surface receptors for these molecules, namely the integrins, which are specific for the ligation of various macromolecules such as the laminins, fibronectins and tenascins. It is now well established that integrins can regulate a variety of biological activities, most notably cell cycle and tissue-specific gene expression. In the intestine, several observations suggest functional roles for cell-matrix interactions in the regulation of epithelial cell functions. This article focuses on integrin α6β4 as a paradigm to illustrate the importance as well as the complexity of integrins in the mediation of cell-matrix interactions. Indeed, α6β4 has been well-characterized for its involvement as a link between the cytoskeleton and extracellular matrix molecules as well as in the activation of a variety of intracellular signalization processes in cooperation with growth factor receptors. Furthermore, recent studies show that distinct forms of α6 and β4 subunits are expressed in the human intestine and, more importantly, recent work provides experimental evidence that various forms of α6β4 can differentially regulate intestinal epithelial cell functions under both normal and pathological conditions. For instance, it has been discovered that colorectal cancer cells express a hybrid form of α6β4 that is never seen in normal cells. Although further work is needed, integrin α6β4 is emerging as a key regulator of intestinal functions in both intestinal health and disease. |
| | |
Authors:
|
Jean-François Beaulieu |
Related Documents
:
|
21614237 - Benign teratoma of the liver: a rare cause of cholangitis. 22473497 - Fenofibrate down-regulates renal oct2-mediated organic cation transport via pparα-inde... 22265967 - Alterations in microrna expression linked to microcystin-lr-induced tumorigenicity in h... 14324977 - Excitability changes of the mauthner cell during collateral inhibition. 18850687 - Geometric control of stem cell differentiation rate on surfaces. 21614237 - Benign teratoma of the liver: a rare cause of cholangitis. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: World journal of gastrointestinal pathophysiology Volume: 1 ISSN: 2150-5330 ISO Abbreviation: World J Gastrointest Pathophysiol Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2011-05-24 Completed Date: 2011-07-14 Revised Date: 2011-07-28 |
Medline Journal Info:
|
Nlm Unique ID: 101547471 Medline TA: World J Gastrointest Pathophysiol Country: China |
Other Details:
|
Languages: eng Pagination: 3-11 Citation Subset: - |
Affiliation:
|
Jean-François Beaulieu, CIHR Team on Digestive Epithelium, Department of Anatomy and Cell Biology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Québec J1H 5N4, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: What is the purpose of launching World Journal of Gastrointestinal Pathophysiology?
Next Document: Molecular mechanisms of cholangiocarcinoma.