Document Detail


Integrative systems biology approaches in asthma pharmacogenomics.
MedLine Citation:
PMID:  22966888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to improve therapeutic outcomes, there is a tremendous need to identify patients who are likely to respond to a given asthma treatment. Pharmacogenomic studies have explained a portion of the variability in drug response and provided an increasing list of candidate genes and SNPs. However, as phenotypic variation arises from a network of complex interactions among genetic and environmental factors, rather than individual genes or SNPs, a multidisciplinary, systems-level approach is required in order to understand the inter-relationships among these factors. Systems biology, which seeks to capture interactions between genetic factors and other variables, offers a promising approach to improved therapeutic outcomes in asthma. This aritcle will review and update progress in the pharmacogenomics of asthma and then discuss the application of systems biology approaches to asthma pharmacogenomics.
Authors:
Amber Dahlin; Kelan G Tantisira
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Pharmacogenomics     Volume:  13     ISSN:  1744-8042     ISO Abbreviation:  Pharmacogenomics     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-12     Completed Date:  2013-05-14     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  100897350     Medline TA:  Pharmacogenomics     Country:  England    
Other Details:
Languages:  eng     Pagination:  1387-404     Citation Subset:  IM    
Affiliation:
Channing Laboratory, Brigham & Women's Hospital & Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Asthma / drug therapy*,  genetics*
Humans
Pharmacogenetics / methods*
Polymorphism, Single Nucleotide
Systems Biology / methods*
Grant Support
ID/Acronym/Agency:
R01 HL092197/HL/NHLBI NIH HHS; R01 HL092197/HL/NHLBI NIH HHS; R01 NR013391/NR/NINR NIH HHS; R01 NR013391/NR/NINR NIH HHS; T32 HL007427/HL/NHLBI NIH HHS; T32 HL007427/HL/NHLBI NIH HHS; U01 HL065899/HL/NHLBI NIH HHS; U01 HL065899/HL/NHLBI NIH HHS
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