Document Detail


Integrative genomic and gene expression analysis of chromosome 7 identified novel oncogene loci in non-small cell lung cancer.
MedLine Citation:
PMID:  19088816     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lung cancer accounts for over a quarter of cancer deaths, with non-small cell lung cancer (NSCLC) accounting for approximately 80% of cases. Several genome studies have been undertaken in both cell models of NSCLC and clinical samples to identify alterations underlying disease behaviour, and many have identified recurring aberrations of chromosome 7. The presence of recurring chromosome 7 alterations that do not span the well-studied oncogenes EGFR (at 7p11.2) and MET (at 7q31.2) has raised the hypothesis of additional genes on this chromosome that contribute to tumourigenesis. In this study, we demonstrated that multiple loci on chromosome 7 are indeed amplified in NSCLC, and through integrative analysis of gene dosage alterations and parallel gene expression changes, we identified new lung cancer oncogene candidates, including FTSJ2, NUDT1, TAF6, and POLR2J. Activation of these key genes was confirmed in panels of clinical lung tumour tissue as compared with matched normal lung tissue. The detection of gene activation in multiple cohorts of samples strongly supports the presence of key genes involved in lung cancer that are distinct from the EGFR and MET loci on chromosome 7.
Authors:
Jennifer M Campbell; William W Lockwood; Timon P H Buys; Raj Chari; Bradley P Coe; Stephen Lam; Wan L Lam
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Validation Studies    
Journal Detail:
Title:  Genome / National Research Council Canada = Génome / Conseil national de recherches Canada     Volume:  51     ISSN:  0831-2796     ISO Abbreviation:  Genome     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-17     Completed Date:  2009-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8704544     Medline TA:  Genome     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1032-9     Citation Subset:  IM    
Affiliation:
Department of Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, 675 West 10th Avenue, Vancouver, BC V5Z1L3 Canada.
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Non-Small-Cell Lung / genetics*
Cell Line, Tumor
Chromosomes, Human, Pair 7*
Gene Amplification
Gene Dosage
Gene Expression Profiling
Genomics / methods
Humans
Lung Neoplasms / genetics*
Oligonucleotide Array Sequence Analysis
Oncogenes* / physiology
Quantitative Trait Loci

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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