| Integrative computational models of cardiac arrhythmias -- simulating the structurally realistic heart. | |
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MedLine Citation:
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PMID: 20628585 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Simulation of cardiac electrical function, and specifically, simulation aimed at understanding the mechanisms of cardiac rhythm disorders, represents an example of a successful integrative multiscale modeling approach, uncovering emergent behavior at the successive scales in the hierarchy of structural complexity. The goal of this article is to present a review of the integrative multiscale models of realistic ventricular structure used in the quest to understand and treat ventricular arrhythmias. It concludes with the new advances in image-based modeling of the heart and the promise it holds for the development of individualized models of ventricular function in health and disease. |
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Authors:
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Natalia A Trayanova; Brock M Tice |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Drug discovery today. Disease models Volume: 6 ISSN: 1740-6757 ISO Abbreviation: - Publication Date: 2009 |
Date Detail:
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Created Date: 2010-10-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101235079 Medline TA: Drug Discov Today Dis Models Country: - |
Other Details:
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Languages: ENG Pagination: 85-91 Citation Subset: - |
Affiliation:
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CSEB 318, Johns Hopkins University, Baltimore, MD 21218. |
Export Citation:
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R01 HL063195-09//NHLBI NIH HHS; R01 HL082729-03//NHLBI NIH HHS; R01 HL082729-04//NHLBI NIH HHS |
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