Document Detail


Integrative computational models of cardiac arrhythmias -- simulating the structurally realistic heart.
MedLine Citation:
PMID:  20628585     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Simulation of cardiac electrical function, and specifically, simulation aimed at understanding the mechanisms of cardiac rhythm disorders, represents an example of a successful integrative multiscale modeling approach, uncovering emergent behavior at the successive scales in the hierarchy of structural complexity. The goal of this article is to present a review of the integrative multiscale models of realistic ventricular structure used in the quest to understand and treat ventricular arrhythmias. It concludes with the new advances in image-based modeling of the heart and the promise it holds for the development of individualized models of ventricular function in health and disease.
Authors:
Natalia A Trayanova; Brock M Tice
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Drug discovery today. Disease models     Volume:  6     ISSN:  1740-6757     ISO Abbreviation:  -     Publication Date:  2009  
Date Detail:
Created Date:  2010-10-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101235079     Medline TA:  Drug Discov Today Dis Models     Country:  -    
Other Details:
Languages:  ENG     Pagination:  85-91     Citation Subset:  -    
Affiliation:
CSEB 318, Johns Hopkins University, Baltimore, MD 21218.
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Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
R01 HL063195-09//NHLBI NIH HHS; R01 HL082729-03//NHLBI NIH HHS; R01 HL082729-04//NHLBI NIH HHS

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