Document Detail

Integration of three-dimensional scar maps for ventricular tachycardia ablation with positron emission tomography-computed tomography.
MedLine Citation:
PMID:  19356409     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: This study sought to assess the feasibility of deriving 3-dimensional (3D) scar maps from positron emission tomography (PET)/computed tomography (CT) hybrid imaging and to integrate those into clinical mapping systems to assist in ventricular tachycardia (VT) ablations. BACKGROUND: Ablation strategies for nonidiopathic VT are increasingly based on the anatomic information of the scar and its border zone. However, the current "gold standard" of voltage mapping is limited by its inability to accurately describe a complex 3D scar morphology, its imperfect spatial resolution, and prolonged procedure times. METHODS: Fourteen patients underwent PET/CT multimodality imaging before the VT ablation. We used PET/CT-derived scar maps to characterize myocardial scar using a 17-segment analysis and surface reconstruction. In 10 patients, reconstructed 3D metabolic scar maps were integrated into a clinical mapping system and compared with high-resolution voltage maps. RESULTS: A good correlation was found between the voltage maps and PET/CT-derived scar maps (r = 0.89; r < 0.05). In addition, 3D metabolic scar maps accurately displayed endocardial and epicardial surface and could be successfully integrated with a registration error of 3.7 +/- 0.7 mm. A combination of visual alignment and surface registration was most accurate for myocardial scar accounting for </=15% of the left ventricular surface. Scar size, location, and border zone accurately predicted high-resolution voltage map findings (r = 0.87; p < 0.05). Integrated scar maps revealed metabolically active channels within the myocardial scar not detected by voltage mapping and correctly predicted non-transmural scar despite normal endocardial voltage recordings. Areas of low voltage within wall segments displaying preserved metabolic activity were shown to be due to suboptimal catheter contact and prevented unnecessary ablation lesions. CONCLUSIONS: We found that PET/CT fusion imaging is able to accurately assess left ventricular scar and its border zone. The integration of a 3D scar map into a clinical mapping system is feasible and may allow supplementary scar characterization that is not available from voltage maps. This technique could significantly facilitate substrate-based VT ablations.
Timm Dickfeld; Peng Lei; Vasken Dilsizian; Jean Jeudy; Jun Dong; Apostolos Voudouris; Robert Peters; Magdi Saba; Raj Shekhar; Stephen Shorofsky
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  JACC. Cardiovascular imaging     Volume:  1     ISSN:  1876-7591     ISO Abbreviation:  JACC Cardiovasc Imaging     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2009-04-09     Completed Date:  2009-04-28     Revised Date:  2009-05-21    
Medline Journal Info:
Nlm Unique ID:  101467978     Medline TA:  JACC Cardiovasc Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  73-82     Citation Subset:  IM    
Division of Cardiology, University of Maryland, Baltimore, Maryland 21201, USA.
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MeSH Terms
Catheter Ablation*
Electrophysiologic Techniques, Cardiac
Endocardium / radiography,  radionuclide imaging
Feasibility Studies
Heart Ventricles / radiography,  radionuclide imaging
Image Interpretation, Computer-Assisted*
Imaging, Three-Dimensional*
Middle Aged
Myocardium / pathology*
Pericardium / radiography,  radionuclide imaging
Positron-Emission Tomography*
Predictive Value of Tests
Preoperative Care
Surgery, Computer-Assisted*
Tachycardia, Ventricular / radiography*,  radionuclide imaging*,  surgery
Tomography, X-Ray Computed*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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