Document Detail


Integration of neurobiology and psychopathology in a unified model of suicidal behavior.
MedLine Citation:
PMID:  1374433     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Suicidal behavior is the result of a combination of factors that span the domains of psychopathology, genetics, early life experience, family interactions, social stress, physical illness, and neurobiology. To develop predictive and explanatory models of suicidal behavior it is necessary to consider all of these domains. A stress-diathesis model is proposed that classifies risk factors for suicidal behavior into those that are trait-dependent and those that are state-dependent. The timing of suicidal behavior is determined by state-dependent factors. The relationship of psychopathologic factors such as severity of depression or anxiety to suicide will be discussed. Biologic changes that correlate with suicide may be either state- or trait-dependent. Particular emphasis will be given to changes in the serotonin system and how these may represent a constitutional risk factor as opposed to a state-dependent risk factor for suicidal behavior.
Authors:
J J Mann; V Arango
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of clinical psychopharmacology     Volume:  12     ISSN:  0271-0749     ISO Abbreviation:  J Clin Psychopharmacol     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-06-09     Completed Date:  1992-06-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8109496     Medline TA:  J Clin Psychopharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2S-7S     Citation Subset:  IM    
Affiliation:
Laboratory of Neuropharmacology, National Institute of Mental Health Clinical Research Center for the Study of Suicidal Behavior, Pittsburgh, Pennsylvania.
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MeSH Terms
Descriptor/Qualifier:
Brain / physiopathology*
Depressive Disorder / genetics,  physiopathology*,  psychology
Humans
Hydroxyindoleacetic Acid / cerebrospinal fluid
Receptors, Serotonin / physiology*
Risk Factors
Serotonin / physiology
Suicide / psychology*
Synaptic Transmission / physiology*
Grant Support
ID/Acronym/Agency:
MH40210/MH/NIMH NIH HHS; MH46745/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Serotonin; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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