Document Detail

Integration of Error Agency and Representation of Others' Pain in the Anterior Insula.
MedLine Citation:
PMID:  23163419     Owner:  NLM     Status:  Publisher    
A crucial feature of socially adaptive behavior is to recognize when our actions harm other individuals. Previous research demonstrates that dorsal mediofrontal cortex (dMFC) and anterior insula (AI) are involved in both action monitoring and empathy for pain. Here, we tested whether these regions could integrate monitoring of error agency with the representation of others' pain. While undergoing event-related fMRI, participants played a visual task in turns with a friend placed outside the scanner, who would receive painful stimulation in half of the error trials. Brain activity was enhanced in dMFC and AI for painful compared with nonpainful errors. Left AI and dorsolateral pFC also exhibited a significant interaction with agency and increased responses when painful errors were caused by one self. We conclude that AI is crucial for integrating inferences about others' feeling states with information about action agency and outcome, thus generating an affective signal that may guide subsequent adjustment.
Leonie Koban; Corrado Corradi-Dell'acqua; Patrik Vuilleumier
Related Documents :
24234259 - Psychological factors related to health, back pain, and dysfunction.
23575999 - Disabling chronic low back pain as an iatrogenic disorder: a qualitative study in abori...
23279749 - The patient acceptable symptom state of chronic musculoskeletal pain measured on a visu...
23510079 - Bdnf regulates atypical pkc at spinal synapses to initiate and maintain a centralized c...
10735729 - Rudolf nissen's years in bosphorus and the pioneers of thoracic surgery in turkey.
25326559 - A tale of comet tail: multiple pellets in the heart.
22337569 - Patient predictor variables for six forms of suicidality.
3969229 - Management of chronic pain.
25386959 - Codeine-induced hyperalgesia and allodynia: investigating the role of glial activation.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-19
Journal Detail:
Title:  Journal of cognitive neuroscience     Volume:  -     ISSN:  1530-8898     ISO Abbreviation:  J Cogn Neurosci     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910747     Medline TA:  J Cogn Neurosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
University of Geneva, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Dopamine D(2) Receptor Modulation of Human Response Inhibition and Error Awareness.
Next Document:  Interacting Cortical and Basal Ganglia Networks Underlying Finding and Tapping to the Musical Beat.