Document Detail


Integrating mouse anatomy and pathology ontologies into a phenotyping database: tools for data capture and training.
MedLine Citation:
PMID:  18797968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Mouse Disease Information System (MoDIS) is a data capture system for pathology data from laboratory mice designed to support phenotyping studies. The system integrates the mouse anatomy (MA) and mouse pathology (MPATH) ontologies into a Microsoft Access database facilitating the coding of organ, tissue, and disease process to recognized semantic standards. Grading of disease severity provides scores for all lesions that can then be used for quantitative trait locus (QTL) analyses and haplotype association gene mapping. Direct linkage to the Pathbase online database provides reference definitions for disease terms and access to photomicrographic images of similar diagnoses in other mutant mice. MoDIS is an open source and freely available program (http://research.jax.org/faculty/sundberg/index.html). This provides a valuable tool for setting up a mouse pathology phenotyping program.
Authors:
John P Sundberg; Beth A Sundberg; Paul Schofield
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-09-17
Journal Detail:
Title:  Mammalian genome : official journal of the International Mammalian Genome Society     Volume:  19     ISSN:  0938-8990     ISO Abbreviation:  Mamm. Genome     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-09-25     Completed Date:  2009-02-04     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  9100916     Medline TA:  Mamm Genome     Country:  United States    
Other Details:
Languages:  eng     Pagination:  413-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Databases, Genetic*
Disease
Information Systems / instrumentation*
Mice
Phenotype
Grant Support
ID/Acronym/Agency:
AG025707/AG/NIA NIH HHS; CA089713/CA/NCI NIH HHS; CA34196/CA/NCI NIH HHS; P30 AG025707/AG/NIA NIH HHS; P30 AG025707-04/AG/NIA NIH HHS; P30 AG025707-05S1/AG/NIA NIH HHS; P30 CA034196-189011/CA/NCI NIH HHS; P30 CA034196-23S2/CA/NCI NIH HHS; R01 CA089713/CA/NCI NIH HHS; R01 CA089713-08/CA/NCI NIH HHS
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