Document Detail


Integrating insulin secretion and ER stress in pancreatic β-cells.
MedLine Citation:
PMID:  23033046     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
After food consumption, insulin-secreting pancreatic β-cells detect increased glucose and incretin hormones, and respond by releasing insulin. Wolfram syndrome 1, a protein that mitigates endoplasmic reticulum (ER) stress, is now shown to regulate insulin synthesis and release - revealing a molecular point of convergence between the ER stress and insulin release pathways.
Authors:
Katleen Lemaire; Frans Schuit
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature cell biology     Volume:  14     ISSN:  1476-4679     ISO Abbreviation:  Nat. Cell Biol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890575     Medline TA:  Nat Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  979-81     Citation Subset:  IM    
Affiliation:
Gene Expression Unit, Department of Molecular and Cellular Medicine, KU Leuven, Herestraat 49, 3000 Leuven, Belgium.
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