| Integrating insulin secretion and ER stress in pancreatic β-cells. | |
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MedLine Citation:
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PMID: 23033046 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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After food consumption, insulin-secreting pancreatic β-cells detect increased glucose and incretin hormones, and respond by releasing insulin. Wolfram syndrome 1, a protein that mitigates endoplasmic reticulum (ER) stress, is now shown to regulate insulin synthesis and release - revealing a molecular point of convergence between the ER stress and insulin release pathways. |
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Authors:
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Katleen Lemaire; Frans Schuit |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nature cell biology Volume: 14 ISSN: 1476-4679 ISO Abbreviation: Nat. Cell Biol. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890575 Medline TA: Nat Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 979-81 Citation Subset: IM |
Affiliation:
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Gene Expression Unit, Department of Molecular and Cellular Medicine, KU Leuven, Herestraat 49, 3000 Leuven, Belgium. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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